Results 271 to 280 of about 21,426,149 (319)
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Drug-Glycosidation and Drug Development
Mini-Reviews in Medicinal Chemistry, 2013Ideally a drug should be administered in a form that it exerts its pharmacological action at the target site using the lowest concentration possible and without undesirable effects. Drug targeting is the approach which is followed for the purpose. Among different approaches preparation of synthetic glycosides of target drug and administering them ...
Vijay K, Kapoor, Amanpreet, Kaur
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Radionuclides in drug development
Drug Discovery Today, 2015Recently, molecular imaging has gained broad interest for the stratification procedures in personalized therapies. In this regard, the importance of radionuclides for the drug development process shall not be underestimated. The methods range from target identification, pharmacokinetics studies, Phase 0 microdosing studies, endoradiotherapy with low ...
Philipp, Uhl +3 more
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Antituberculosis drugs and new drug development
Current Opinion in Pulmonary Medicine, 2001Tuberculosis affects more than 8 million people and has serious repercussions on economic, psychologic, and social status. Since its declaration as a global emergency in 1993 by the World Health Organization, significant development in the treatment and control of tuberculosis has been the implementation of the short-course directly observed treatment ...
S, Agrawal +4 more
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Drug Repurposing for Drug Development in Stroke
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2010The development of new treatments for acute stroke has been fraught with costly and spectacularly disappointing failures. Repurposing of drugs already known to be safe provides a lower risk alternative. Investigators are using drug repurposing, in which marketed drugs are exploited for their secondary activity, to pursue agents that have multiple ...
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Polysomnography in Drug Development
The Journal of Clinical Pharmacology, 1997Polysomnography in drug development is used to detect desirable and undesirable effects of drugs on normal and disturbed sleep. Although this method is essential for the approval of new hypnotic drugs, it is quite often neglected in the development of drugs that show unwanted side effects on normal sleep.
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Metabonomics and Drug Development
2015Metabolites as an end product of metabolism possess a wealth of information about altered metabolic control and homeostasis that is dependent on numerous variables including age, sex, and environment. Studying significant changes in the metabolite patterns has been recognized as a tool to understand crucial aspects in drug development like drug ...
Pranov, Ramana +3 more
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Active drug metabolites in drug development
Current Opinion in Pharmacology, 2003Active drug metabolites discovered during the course of drug development constitute a subset of the larger issue of metabolic drug interactions, but still demand unique consideration from both an efficacy and a safety point of view. Improved technology has allowed better identification and quantification of metabolites, raising new issues to be ...
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2004
The development of new drugs involves an extensive pre-clinical characterization and safety documentation followed by a time-consuming search for appropriate clinical dose levels. Drug development is a time-consuming and costly procedure: The molecule-todrug-time is about 15 years, whereas an investment of about 500 million to 1 billion euro is ...
C, Halldin, B, Gulyás, L, Farde
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The development of new drugs involves an extensive pre-clinical characterization and safety documentation followed by a time-consuming search for appropriate clinical dose levels. Drug development is a time-consuming and costly procedure: The molecule-todrug-time is about 15 years, whereas an investment of about 500 million to 1 billion euro is ...
C, Halldin, B, Gulyás, L, Farde
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Ethics of Drug Research and Drug Development
1989Medical benefits of clinical research during the past hundred years include effective vaccines and drugs for fighting most infections, the virtual eradication of epidemic diseases such as smallpox and cholera, an impressive reduction in infant mortality and the prevention of diseases such as polio and pertussis, transplantation of vital organs such as ...
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European Journal of Cancer and Clinical Oncology, 1991
INTRODUCTION AT THE start of the 1990s it is apparent that the evolution of chemotherapy is entering a crucial phase. After the first demonstration of the successful use of anticancer agents in human cancer over 30 years ago, there followed a period of 20 years of clinical research, !argely based on empiricism, which gave rise to some remarkable ...
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INTRODUCTION AT THE start of the 1990s it is apparent that the evolution of chemotherapy is entering a crucial phase. After the first demonstration of the successful use of anticancer agents in human cancer over 30 years ago, there followed a period of 20 years of clinical research, !argely based on empiricism, which gave rise to some remarkable ...
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