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Radionuclides in drug development
Drug Discovery Today, 2015Recently, molecular imaging has gained broad interest for the stratification procedures in personalized therapies. In this regard, the importance of radionuclides for the drug development process shall not be underestimated. The methods range from target identification, pharmacokinetics studies, Phase 0 microdosing studies, endoradiotherapy with low ...
Philipp, Uhl +3 more
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Metabonomics and Drug Development
2015Metabolites as an end product of metabolism possess a wealth of information about altered metabolic control and homeostasis that is dependent on numerous variables including age, sex, and environment. Studying significant changes in the metabolite patterns has been recognized as a tool to understand crucial aspects in drug development like drug ...
Pranov, Ramana +3 more
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Antituberculosis drugs and new drug development
Current Opinion in Pulmonary Medicine, 2001Tuberculosis affects more than 8 million people and has serious repercussions on economic, psychologic, and social status. Since its declaration as a global emergency in 1993 by the World Health Organization, significant development in the treatment and control of tuberculosis has been the implementation of the short-course directly observed treatment ...
S, Agrawal +4 more
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Polysomnography in Drug Development
The Journal of Clinical Pharmacology, 1997Polysomnography in drug development is used to detect desirable and undesirable effects of drugs on normal and disturbed sleep. Although this method is essential for the approval of new hypnotic drugs, it is quite often neglected in the development of drugs that show unwanted side effects on normal sleep.
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2004
The development of new drugs involves an extensive pre-clinical characterization and safety documentation followed by a time-consuming search for appropriate clinical dose levels. Drug development is a time-consuming and costly procedure: The molecule-todrug-time is about 15 years, whereas an investment of about 500 million to 1 billion euro is ...
C, Halldin, B, Gulyás, L, Farde
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The development of new drugs involves an extensive pre-clinical characterization and safety documentation followed by a time-consuming search for appropriate clinical dose levels. Drug development is a time-consuming and costly procedure: The molecule-todrug-time is about 15 years, whereas an investment of about 500 million to 1 billion euro is ...
C, Halldin, B, Gulyás, L, Farde
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European Journal of Cancer and Clinical Oncology, 1991
INTRODUCTION AT THE start of the 1990s it is apparent that the evolution of chemotherapy is entering a crucial phase. After the first demonstration of the successful use of anticancer agents in human cancer over 30 years ago, there followed a period of 20 years of clinical research, !argely based on empiricism, which gave rise to some remarkable ...
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INTRODUCTION AT THE start of the 1990s it is apparent that the evolution of chemotherapy is entering a crucial phase. After the first demonstration of the successful use of anticancer agents in human cancer over 30 years ago, there followed a period of 20 years of clinical research, !argely based on empiricism, which gave rise to some remarkable ...
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Drug Repurposing for Drug Development in Stroke
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2010The development of new treatments for acute stroke has been fraught with costly and spectacularly disappointing failures. Repurposing of drugs already known to be safe provides a lower risk alternative. Investigators are using drug repurposing, in which marketed drugs are exploited for their secondary activity, to pursue agents that have multiple ...
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Ethics of Drug Research and Drug Development
1989Medical benefits of clinical research during the past hundred years include effective vaccines and drugs for fighting most infections, the virtual eradication of epidemic diseases such as smallpox and cholera, an impressive reduction in infant mortality and the prevention of diseases such as polio and pertussis, transplantation of vital organs such as ...
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Antiepileptic drugs in development
The Lancet Neurology, 2006Despite the success of several new antiepileptic drugs, about one third of patients with epilepsy are not seizure free on medication. Improvement in this situation might lie in drugs that are currently in development.Some new antiepileptic drugs are modifications of those already available, referred to in this Rapid Review as evolutionary drugs.
John R, Pollard, Jacqueline, French
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Toxicogenetics in drug development
Toxicology Letters, 2001The major progress made in the understanding of the genetic basis of inter-individual variation in drug response, alongside the rapid advances in technology, provides major new opportunities to ensure the safe introduction of a new chemical entity into clinical practice.
B K, Park, M, Pirmohamed
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