Results 271 to 280 of about 4,166,507 (358)

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Clinical pharmacology-how it shapes the drug development journey. [PDF]

Eur J Clin Pharmacol
Kruse M, Stankeviciute S, Perry S.
europepmc   +1 more source

Enantioselective metabolism of drugs and the association for drug development.

, 1993
Yasushi Yamazoe
openalex   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Advancing the Integration of Digital Health Technologies in the Drug Development Ecosystem.

J Med Internet Res
Sardar S, Coon CD, Kern S, Huynh H, Stephenson D, Abrams JR, Lee GV, Ollivier C, Hedrick JA, Müller ML, Evers LJW, Leyens L, Hovinga C, Ma SC, Romero K.   +14 more
europepmc   +1 more source

Model-Informed Paradigm in Drug Development-An End-To-End Case Study From Upadacitinib Development. [PDF]

Clin Transl Sci
Bhatnagar S, Stodtmann S, Qian Y, Marroum P, Liu W, Mohamed MF.   +5 more
europepmc   +1 more source

Toxicokinetics as part of the safety evaluation of a new drug under development

, 1992
Hideyo Noguchi
openalex   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Virtual Patients in Clinical Trials for Drug Development: A Narrative Review. [PDF]

Cureus
Kleeberger JA.
europepmc   +1 more source

Drug metabolism research in development of innovative drugs.

, 1993
Tetsuya Kamataki
openalex   +1 more source