Results 121 to 130 of about 5,239,733 (368)

Herbo-mineral formulation ‘Ashwashila’ attenuates rheumatoid arthritis symptoms in collagen-antibody-induced arthritis (CAIA) mice model

Scientific Reports, 2019
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that affects joints of hands and feet and introduces injury in secondary organs such as cardiac tissue.
Acharya Balkrishna, Sachin Shridhar Sakat, Kheemraj Joshi, Sandeep Paudel, Deepika Joshi, Kamal Joshi, Ravikant Ranjan, Abhishek Gupta, Kunal Bhattacharya, Anurag Varshney   +9 more
doaj   +1 more source

Concise Review: Drug Discovery in the Age of the Induced Pluripotent Stem Cell [PDF]

, 2014
Huaising C. Ko, Bruce D. Gelb
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Drug Discovery for Human African Trypanosomiasis: Identification of Novel Scaffolds by the Newly Developed HTS SYBR Green Assay for Trypanosoma brucei [PDF]

, 2014
Joana Faria, Carolina Borsoi Moraes, Rita Song, Bruno S. Pascoalino, Nakyung Lee, Jair L. Siqueira-Neto, Deu John M. Cruz, Tanya Parkinson, Jean‐Robert Ioset, Anabela Cordeiro‐da‐Silva, Lúcio H. Freitas-Júnior   +10 more
openalex   +1 more source

Adverse Drug Reaction Discovery Using a Tumor-Biomarker Knowledge Graph

, 2021
Meng Wang, Xinyu Ma, Jingwen Si, Hongjia Tang, Haofen Wang, Tunliang Li, Wen Ouyang, Liying Gong, Yongzhong Tang, Xi He, Wei Huang, Xing Liu   +11 more
openalex   +1 more source

CcpNmr AnalysisScreen, a new software programme with dedicated automated analysis tools for fragment-based drug discovery by NMR [PDF]

, 2020
Luca Mureddu, Timothy J. Ragan, Edward J. Brooksbank, Geerten W. Vuister   +3 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery [PDF]

, 2019
Alexandra Friese, Andrei Ursu, Andreas Hochheimer, Hans R. Schöler, Herbert Waldmann, Jan M. Bruder   +5 more
openalex   +1 more source

2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery

, 2023
Aaron M. Bender, Lauren C. Parr, William B. Livingston, Craig W. Lindsley, W. David Merryman   +4 more
openalex   +2 more sources