Results 191 to 200 of about 1,359,668 (353)

Graph based link prediction for epilepsy drug discovery. [PDF]

Sci Rep
Shi X, Sundareswaran R, Shanmugapriya M, Jayaguptha N, Khan A.   +4 more
europepmc   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Advances in Drug Discovery for Cardiomyocyte Proliferation. [PDF]

Curr Treat Options Cardiovasc Med
Wintruba KL, Wolf MJ, van Berlo JH, Saucerman JJ.   +3 more
europepmc   +1 more source

New Drug Discovery in the Postgenomic Era: From Genomics to Proteomics

, 2000
Stephen M. Stahl
openalex   +2 more sources

B2B Infrastructures in the Process of Drug Discovery and Healthcare

In this paper we describe a demonstration of an innovative B2B infrastructure which can be used to support collaborations in the pharmaceutical industry to achieve the drug discovery goal.
Boniface, M.J., Radetzki, U., Walland, Paul. W.   +2 more
core  

The tumor–microbe connection

Molecular Oncology, EarlyView.
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Gerlanda Vella, Maria Rescigno
wiley   +1 more source

ChemBounce: a computational framework for scaffold hopping in drug discovery. [PDF]

Bioinformatics
Jang WD, Gu C, Noh Y, Oh KS, Ryu JY.
europepmc   +1 more source

The Oceans and Human Health: The Discovery and Development of Marine-Derived Drugs [PDF]

, 2001
Shirley A. Pomponi
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Methods to accelerate PROTAC drug discovery. [PDF]

Biochem J
Osman J, Thompson PE, Jörg M, Scanlon MJ.   +3 more
europepmc   +1 more source