Results 191 to 200 of about 568,926 (318)

The integration of functional genomics, combinatorial chemistry and nanotechnology into a miniaturized drug discovery process [PDF]

, 2001
Manfred Auer
openalex   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Advancing Covalent Ligand and Drug Discovery beyond Cysteine. [PDF]

Chem Rev
Kim G, Grams RJ, Hsu KL.
europepmc   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Drug discovery in reverse [PDF]

Nature, 2004
openaire   +3 more sources

AI meets physics in computational structure-based drug discovery for GPCRs. [PDF]

NPJ Drug Discov
Michino M, Vendome J, Kufareva I.
europepmc   +1 more source

High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery

, 2001
Michael W. Pantoliano, Eugene C. Petrella, Joseph D. Kwasnoski, Victor S. Lobanov, James C. Myslik, E. R. Graf, Ted Carver, Eric D. Asel, Barry A. Springer, Pamela Lane, F.R. Salemme   +10 more
openalex   +1 more source

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

FEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source

Digital Alchemy: The Rise of Machine and Deep Learning in Small-Molecule Drug Discovery. [PDF]

Int J Mol Sci
Manan A, Baek E, Ilyas S, Lee D.
europepmc   +1 more source

Use of Genomics in Drug Discovery: Application to Target Identification, High-Throughput Screening and Diagnosis

, 2001
Hisafumi Yamada‐Okabe
openalex   +2 more sources