Results 201 to 210 of about 1,359,668 (353)

Biodiversity conservation and drug discovery in Suriname. Explorations in nature's combinatorial library [PDF]

, 2001
David G. I. Kingston
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Lenacapavir's success: Revitalizing antiviral drug discovery. [PDF]

Virulence
Miranda D, Sanchez DJ.
europepmc   +1 more source

STAT proteins: novel molecular targets for cancer drug discovery

, 2000
James Turkson, Richard Jove
openalex   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

A new paradigm for drug discovery in the treatment of complex diseases: drug discovery and optimization. [PDF]

Chin Med
Yuan Y, Yu L, Bi C, Huang L, Su B, Nie J, Dou Z, Yang S, Li Y.   +8 more
europepmc   +1 more source

The Impact of Whole Genome Sequence Data on Drug Discovery—A Malaria Case Study [PDF]

, 2001
Marcin P. Joachimiak, Calvin Chang, Philip J. Rosenthal, Fred E. Cohen   +3 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Sequence-Based Protein-Protein Interaction Prediction and Its Applications in Drug Discovery. [PDF]

Cells
Charih F, Green JR, Biggar KK.
europepmc   +1 more source

Natural Product-Based Anti-HIV Drug Discovery and Development Facilitated by the NCI Developmental Therapeutics Program. [PDF]

, 2001
Stringner S. Yang, Gordon M. Cragg, David Newman, John P. Bader   +3 more
openalex   +1 more source