Results 211 to 220 of about 5,785,146 (400)
The Ethnomedicinal Uses of Magnoliaceae from the Southeastern United States as Leads in Drug Discovery [PDF]
, 2001 Wolfgang Schühly +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Lenacapavir's success: Revitalizing antiviral drug discovery. [PDF]
VirulenceMiranda D, Sanchez DJ.
europepmc +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
Nature reviews. Drug discovery, 2021 E. Patton, L. Zon, D. Langenau
semanticscholar +1 more source
A new paradigm for drug discovery in the treatment of complex diseases: drug discovery and optimization. [PDF]
Chin MedYuan Y +8 more
europepmc +1 more source
The Impact of Whole Genome Sequence Data on Drug Discovery—A Malaria Case Study [PDF]
, 2001 Marcin P. Joachimiak +3 more
openalex +1 more source