Results 211 to 220 of about 5,239,733 (368)

Special Issue: Protein-Protein Interactions: New Perspectives in Drug Discovery. [PDF]

Int J Mol Sci
Szénási T.
europepmc   +1 more source

Mitochondria‐targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: A new strategy in anti‐apoptotic drug discovery

, 2008
Valerian E. Kagan, Ayşe Güneş Bayır, Hülya Bayır, Detcho A. Stoyanovsky, Grigory G. Borisenko, Yulia Y. Tyurina, Peter Wipf, Jeffrey Atkinson, Joel S. Greenberger, Robert S. Chapkin, Natalia A. Belikova   +10 more
openalex   +1 more source

Gene expression as a drug discovery tool [PDF]

, 2004
William E. Evans, R. Kiplin Guy
openalex   +1 more source

New avenues in artificial-intelligence-assisted drug discovery

, 2023
Carmen Cerchia, Antonio Lavecchia
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Reporter-expressing viruses for antiviral drug discovery research. [PDF]

Front Cell Infect Microbiol
Praditya DF, Waluyo D, Nozaki T.
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Drug Discovery and Repurposing for <i>Coccidioides</i>: A Systematic Review. [PDF]

J Fungi (Basel)
Saeger S, Lozano S, Wiederhold N, Yu JJ, Lopez-Ribot JL, Hung CY.   +5 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

The ABCs of psychedelics: a preclinical roadmap for drug discovery. [PDF]

Trends Pharmacol Sci
Kwan AC, Mantsch JR, McCorvy JD.
europepmc   +1 more source