Results 271 to 280 of about 1,411,950 (341)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Quantitative Approaches to Accelerate MASH Drug Discovery and Development. [PDF]

Clin Pharmacol Ther
Abouelhassan Y, Tallapaka S, Mehrani R, Siler SQ, Qin L, Wang Z, Trujillo ME.   +6 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Fragment-based drug discovery: A graphical review. [PDF]

Curr Res Pharmacol Drug Discov
AlKharboush DF, Kozielski F, Wells G, Porta EOJ.   +3 more
europepmc   +1 more source

Fighting Bugs by Numbers : Bioinformatics Tools for Antimicrobial Drug Discovery

, 2017
Andreas Helfenstein
openalex   +1 more source

The Generative Revolution: AI/Machine Learning in Transforming Drug Discovery, Repurposing, and Translational Medicine

Suthar, Deepak Bharat
openalex   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Protein Engineering and Drug Discovery: Importance, Methodologies, Challenges, and Prospects. [PDF]

Biomolecules
Mohammed A, Ibrahim NA, Basher NS.
europepmc   +1 more source

Table 1_Identification of novel drug targets and small molecule discovery for MRSA infections.xlsx

Nandha Kumar Subramani (21090065), Subhashree Venugopal (20936801)   +1 more
openalex   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source