Results 281 to 290 of about 5,785,146 (400)

canSAR 2024-an update to the public drug discovery knowledgebase. [PDF]

Nucleic Acids Res
Gingrich PW, Chitsazi R, Biswas A, Jiang C, Zhao L, Tym JE, Brammer KM, Li J, Shu Z, Maxwell DS, Tacy JA, Mica IL, Darkoh M, di Micco P, Russell KP, Workman P, Al-Lazikani B.   +16 more
europepmc   +1 more source

Radiotherapy medical physics in the Philippines: A contemporary overview

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose With cancer ranking as the third leading cause of death in the Philippines and a disparity in healthcare resources across regions, this research aimed to assess the state of radiotherapy medical physics in the country. Methodology The study utilized a comprehensive online survey with 94 structured questions answered by 19 clinics ...
John Paul C. Cabahug, Ramon Carlo Cruzpero, Luis E. Fong de los Santos, Eric C. Ford, Afua A. Yorke   +4 more
wiley   +1 more source

MHNfs: Prompting In-Context Bioactivity Predictions for Low-Data Drug Discovery. [PDF]

J Chem Inf Model
Schimunek J, Luukkonen S, Klambauer G.
europepmc   +1 more source

Accuracy and reproducibility of a single‐pose image‐to‐robot registration method for mobile C‐arm cone beam CT guided histotripsy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Histotripsy is a focal tumor therapy that utilizes focused ultrasound (US) to mechanically destroy tissue. To overcome visualization limitations of diagnostic US‐guidance, C‐arm cone beam CT (CBCT)‐guided histotripsy is being developed, for which a mobile C‐arm could increase accessibility. CBCT‐guided histotripsy uses a phantom with a
Grace M. Minesinger, Paul F. Laeseke, Katrina L. Falk, Claire E. Hennen, Michael A. Speidel, Martin G. Wagner   +5 more
wiley   +1 more source

Use of Genomics in Drug Discovery: Application to Target Identification, High-Throughput Screening and Diagnosis

, 2001
Hisafumi Yamada‐Okabe
openalex   +2 more sources

HPDL Variant Type Correlates With Clinical Disease Onset and Severity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic paraplegia. HPDL converts 4‐hydroxyphenylpyruvate acid (4‐HPPA) into 4‐hydroxymandelate (4‐HMA),
Eun Hye Lee, Olivia Kim‐Mcmanus, Jennifer H. Yang, Richard Haas, Maha S. Zaki, Ghada M. H. Abdel‐Salam, Yuji Nakamura, Mohamed S. Abdel‐Hamind, Darius Ebrahimi‐Fakhari, Julian E. Alecu, Nicola Brunetti‐Pierri, Varunvenkat M. Srinivasan, Vykuntaraju K. Gowda, Stephanie Gross, Yasemin Alanay, Paria Najarzadeh Totbati, Manya Yadavilli, Liana Friedman, Naomi Meave Ojeda, Joseph G. Gleeson   +19 more
wiley   +1 more source

Trends in GPCR drug discovery: new agents, targets and indications

Nature reviews. Drug discovery, 2017
A. Hauser, Misty M. Attwood, M. Rask-Andersen, H. Schiöth, David E. Gloriam   +4 more
semanticscholar   +1 more source

Galleria mellonella as a drug discovery model to study oxidative stress. [PDF]

Sci Rep
Edzeamey FJ, Ramchunder Z, McCarthy RR, Virmouni SA.   +3 more
europepmc   +1 more source

Closing down on glyphosate inhibition—with a new structure for drug discovery

, 2001
Murtaza F. Alibhai, William C. Stallings
openalex   +1 more source

A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). Methods Expression profiles of GBM were downloaded from the XENA database as a training dataset to construct a ...
Jun Yang, Da Lin, Dongyuan Liu, Dongxu Zhang, Hao Wang   +4 more
wiley   +1 more source