Results 241 to 250 of about 803,380 (297)
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Kinase Inhibitors in Drug-design, Drug-discovery, and Drug-delivery
Current Medicinal Chemistry, 2023openaire +2 more sources
Designing chiral libraries for drug discovery
Drug Discovery Today, 2000Identification of new biological targets combined with combinatorial medicinal chemistry has enormous potential to facilitate the discovery of new therapeutics. However, these new targets might require the use of different or more complex screening libraries.
, Beroza, , Suto
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Current Prodrug Design for Drug Discovery
Current Pharmaceutical Design, 2009Prodrugs are inactive compounds which are metabolized either chemically or enzymatically in a controlled or predictable manner to the parent active drug inside the body. Prodrugs can enhance the therapeutic efficacy and/or reduce adverse effects via different mechanisms, including increased solubility, improved permeability and bioavailability ...
Pei-Wen, Hsieh +2 more
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Pharmacophores in Drug Design and Discovery
SAR and QSAR in Environmental Research, 1998Compounds containing a specific pharmacophore--the minimum structural features necessary for enzyme binding--can be retrieved from a database such as the National Cancer Institute repository by means of three-dimensional (3D) searching, which allows the retrieval of all compounds possessing a specified set of atoms with a given 3D geometry. The ways in
G W, Milne, M C, Nicklaus, S, Wang
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Fragment Based Drug Discovery using rational design
The FASEB Journal, 2007Fragment‐based discovery has recently emerged as a new approach for the generation of novel small molecule therapeutic agents. The use of high throughput X‐ray crystallography, as well as NMR, in fragment‐based discovery approaches will be exemplified in this talk.
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Chemical Intuition in Drug Design and Discovery
Current Topics in Medicinal Chemistry, 2019The medicinal chemist plays the most important role in drug design, discovery and development. The primary goal is to discover leads and optimize them to develop clinically useful drug candidates. This process requires the medicinal chemist to deal with large sets of data containing chemical descriptors, pharmacological data, pharmacokinetics ...
Júlia G B, Pedreira +2 more
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Recent Trends in Drug Design and Discovery
Current Topics in Medicinal Chemistry, 2020Introduction:Structure-based drug design is a wide area of identification of selective inhibitors of a target of interest. From the time of the availability of three dimensional structure of the drug targets, mostly the proteins, many computational methods had emerged to address the challenges associated with drug design process.
Devadasan, Velmurugan +2 more
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New Paradigms in Drug Design and Discovery
Frontiers in Medicinal Chemistry - Online, 2002The new millennium has ushered in an era of science that will revolutionize a great majority of our daily activities. That revolution is being experienced by a growing number of the population who are pushing the average life expectancy closer to the 80-year mark.
Nouri, Neamati, Joseph J, Barchi
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