Results 251 to 260 of about 803,380 (297)
Some of the next articles are maybe not open access.
Internet Resources for Drug Discovery and Design
Current Topics in Medicinal Chemistry, 2019The review describes online resources used for drug discovery and design. Internet resources can be classified into two classes. The first class of resources accumulates information about drugs, drug candidates, compounds, and bioassays. This information is a starting point in drug discovery and design.
Vladimir, Potemkin +2 more
openaire +2 more sources
Designing Transcription Factor Architectures for Drug Discovery
Molecular Pharmacology, 2004Recent advances in the design, selection, and engineering of DNA binding proteins have led to the emerging field of designer transcription factors (TFs). Modular DNA-binding protein domains can be assembled to recognize a given sequence of a DNA in a regulatory region of a targeted gene. TFs can be readily prepared by linking the DNA-binding protein to
Pilar, Blancafort +2 more
openaire +2 more sources
Drug Discovery, Design and Delivery
2012Abstract : The project aims to develop novel strategies to treat or prevent infectious caused by bacteria which pose as biothreat agents (Bacillus anthracis) or are recognized causes of emerging disease {Bartonella species).
Mark Mclaughlin +3 more
openaire +1 more source
Domino Reactions in Drug Design and Discovery
Current Drug Discovery Technologies, 2016With reference to challenges in developing varied and exceedingly complex scaffolds expeditiously through atom economy, domino reactions have assumed a significant role in several transformative endeavors towards established pharmaceuticals and new chemical entities across diverse therapeutic classes such as HIV integrase inhibitors, DPP4 [dipeptidyl ...
Shanta, Bhar, Mucheli M V, Ramana
openaire +2 more sources
Functionalized Carbon Nanotubes in Drug Design and Discovery
Accounts of Chemical Research, 2007Carbon nanotubes (CNTs) have been proposed and actively explored as multipurpose innovative carriers for drug delivery and diagnostic applications. Their versatile physicochemical features enable the covalent and noncovalent introduction of several pharmaceutically relevant entities and allow for rational design of novel candidate nanoscale constructs ...
PRATO, MAURIZIO +2 more
openaire +4 more sources
Optimal Serial Dilutions Designs for Drug Discovery Experiments
Journal of Biopharmaceutical Statistics, 2011Dose-response studies are an essential part of the drug discovery process. They are typically carried out on a large number of chemical compounds using serial dilution experimental designs. This paper proposes a method of selecting the key parameters of these designs (maximum dose, dilution factor, number of concentrations and number of replicated ...
Donev, Alexander N., Tobias, Randall D.
openaire +3 more sources
Designing around Structural Alerts in Drug Discovery
Journal of Medicinal Chemistry, 2019Cumulative research over several decades has implicated the involvement of reactive metabolites in many idiosyncratic adverse drug reactions (IADRs). Consequently, "avoidance" strategies have been inserted into drug discovery paradigms, which include the exclusion of structural alerts and possible termination of reactive metabolite-positive compounds ...
openaire +2 more sources
Computational Drug Discovery and Design
2012Computational drug discovery and design , Computational drug discovery and design , کتابخانه مرکزی دانشگاه علوم پزشکی ...
openaire +1 more source
Antibacterial drug discovery and structure-based design
Drug Discovery Today, 2006Bacterial resistance continues to develop and pose a significant threat, both in hospitals and, more recently, in the community. A focus on other therapeutic areas by the larger pharmaceutical companies has left a shortfall in the pipeline of novel antibacterials.
openaire +2 more sources
Fragment-Based Drug Discovery and Molecular Docking in Drug Design
Current Pharmaceutical Biotechnology, 2015Fragment-based drug discovery (FBDD) has caused a revolution in the process of drug discovery and design, with many FBDD leads being developed into clinical trials or approved in the past few years. Compared with traditional high-throughput screening, it displays obvious advantages such as efficiently covering chemical space, achieving higher hit rates,
Tao, Wang +5 more
openaire +2 more sources