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[Preclinical evaluation of anticancer drugs: a model remaining a model!].
Bulletin du cancer, 1998Two criteria are firstly used in the selection of new anticancer agents:--originality of the mechanism of action and significant experimental antitumor activity in an in vivo animal model. Murine tumors grafted in syngenic mice and human tumor xenografts implanted in nude mice are old models which continue to be widely used.
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Mitigating risk in academic preclinical drug discovery
Nature Reviews Drug Discovery, 2015Michael A Walters +2 more
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Human malignant melanoma: preclinical and clinical drug evaluation.
Behring Institute Mitteilungen, 1984A panel of 17 melanoma xenograft lines was exposed to various DNA reactive agents. Growth delay values were calculated from tumor volume responses of xenograft bearing mice and correlated with donor patient's response as determined by standard clinical criteria.
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[The problem of preclinical evaluation of psychotropic drugs].
Acta neurologica, 1970M, Tansella, G, Dello Russo
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[Place of in vitro models in preclinical evaluation of anticancer drugs].
Bulletin du cancer, 1996In vitro models have been intensively developed for several years for selecting new anticancer agents. The National Cancer Institute has even chosen as a primary screen of new molecules a panel of 60 human tumor cell lines. However, it may seem hazardous to rely too much on in vitro models for the discovery and selection of new anticancer drugs: (1 ...
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Insights from Preclinical Choice Models on Treating Drug Addiction
Trends in Pharmacological Sciences, 2017S Stevens Negus, Matthew Banks
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