Results 281 to 290 of about 307,775 (306)

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Nature Reviews Drug Discovery, 2019
Richard J Weaver, Amy E Chadwick, Christopher E Goldring   +2 more
exaly  

Prediction of antibiotic resistance: time for a new preclinical paradigm?

Nature Reviews Microbiology, 2017
Morten O A Sommer, Christian Munck, Dan Andersson   +2 more
exaly  

[Preclinical evaluation of anticancer drugs: a model remaining a model!].

Bulletin du cancer, 1998
Two criteria are firstly used in the selection of new anticancer agents:--originality of the mechanism of action and significant experimental antitumor activity in an in vivo animal model. Murine tumors grafted in syngenic mice and human tumor xenografts implanted in nude mice are old models which continue to be widely used.
openaire   +1 more source

The global preclinical antibacterial pipeline

Nature Reviews Microbiology, 2019
Ursula Theuretzbacher, Kevin Outterson, Aleks Engel   +2 more
exaly  

Orthotopic models of cancer for preclinical drug evaluation

European Journal of Cancer, 2004
openaire   +1 more source

Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets

Nature Reviews Drug Discovery, 2016
Anton Bespalov, Bruce Altevogt, Dario Doller   +2 more
exaly  

Evolution of strategies to improve preclinical cardiac safety testing

Nature Reviews Drug Discovery, 2016
Gary Gintant, Norman Stockbridge
exaly  

Evaluation of Drug Candidates for Preclinical Development

2009
openaire   +1 more source

Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome

Nature Reviews Drug Discovery, 2017
George Apostol, Mark F Bear, Aurore Curie   +2 more
exaly  

Organs-on-chips at the frontiers of drug discovery

Nature Reviews Drug Discovery, 2015
Dongeun Huh
exaly