Recommendations for Standards Regarding Preclinical Neuroprotective and Restorative Drug Development [PDF]
, 1999 —The plethora of failed clinical trials with neuroprotective drugs for acute ischemic stroke have raised justifiable concerns about how best to proceed for the future development of such interventions.
core +1 more source
Ozone therapy improves early stages of osseointegration in ovariectomized rats [PDF]
Journal of Applied Oral ScienceObjective the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats.
William Phillip Pereira da SILVA +8 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application [PDF]
, 2023 INTRODUCTION: Topical drug delivery is highly attractive and yet faces tissue barrier challenges. Different physical and chemical methods have been explored to facilitate topical drug delivery.
Kang, Xinliang +9 more
core +1 more source
Preclinical species gene expression database: Development and meta-analysis
Frontiers in Genetics, 2023 The evaluation of toxicity in preclinical species is important for identifying potential safety liabilities of experimental medicines. Toxicology studies provide translational insight into potential adverse clinical findings, but data interpretation may ...
Caitlin Krause +10 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
MoleculesCeftobiprole is a fifth-generation beta-cephalosporin with high inter-individual pharmacokinetic variability in critically ill patients. However, data on its pharmacokinetics and central nervous system (CNS) penetration are limited.
Sabahat Ablimit +8 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Preclinical pharmacokinetic evaluation of novel antimalarial and antituberculosis drug leads [PDF]
, 2019 Preclinical pharmacokinetics relies on efficient and accurate screening to select clinical candidates from early leads. Poor pharmacokinetic interpretation can disadvantage drug discovery by promoting inadequate compounds and expelling potential drug ...
Strydom, Natasha
core +1 more source
Preclinical Evaluations of Drug Candidates Using a Cell Viability Assay and Sensorimotor Evaluation Study [PDF]
, 2023 Preclinical evaluation following the synthesis of potential drugs candidates is an important part of drug discovery. The purpose of preclinical evaluation is to determine safety and adverse effects of new compounds.
Kiley, Molly
core