Results 31 to 40 of about 192,321 (311)

Innovative preclinical models for pulmonary drug delivery research. [PDF]

, 2020
Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs.
Vecellio, L., Barosova, Hana, Schmid, O., Schmid, Otmar, Sznitman, Josue, Vecellio, Laurent, Barosova, H., Rothen-Rutishauser, Barbara, Yang, L., Sznitman, J., Henze-Vourc´h, N., Yang, Lin, Ehrmann, S., Mitchell, Jolyon, Heuzé-Vourc'H, Nathalie, Ehrmann, Stephan, Darquenne, Chantal, Heuze-Vourc’h, Nathalie, Darquenne, C., Mitchell, J., Rothen-Rutishauser, B.   +20 more
core   +1 more source

Preclinical in vivo Neurotoxicity Studies of Drug Candidates [PDF]

, 2020
Neurotoxic effects are one of the common reasons for discontinuation of preclinical and/or clinical studies. Preclinical evaluation of neurotoxic effects is complicated due to a wide range of manifestations and degrees of severity.
L. G. Kolik, R. U. Ostrovskaya, A. D. Durnev, N. V. Eremina   +3 more
core   +2 more sources

Drug-induced taste disorders in clinical practice and preclinical safety evaluation [PDF]

, 2017
More than 200 medications can induce taste disorders in patients. They not only reduce quality of life for those affected, but can lead to malnutrition, severe dehydration and difficulty in maintaining a therapeutic regimen.
Hummel, Thomas, Mansfield, Keith, Wang, Tao, Grushka, Miriam, Glendinning, John   +4 more
core   +1 more source

Preclinical Formulation in Early Drug Research [PDF]

, 2011
The success of the drug research and development process depends not only on the intrinsic qualities of the molecules, but also on the way in which these qualities can be revealed.
Ottilia Balazs
core   +1 more source

Preclinical models for pulmonary drug delivery [PDF]

, 2009
BACKGROUND: The lung comprises an interesting route of administration not only for topical drugs but also for systemically acting drugs. Over the last years, several models have been developed in order to study the efficacy and safety of pulmonary drug ...
Fernandes, Cláudia A., Vanbever, Rita
core   +1 more source

Synthesis and Preclinical Evaluation of Radiolabeled [103Ru]BOLD-100 [PDF]

, 2023
The first-in-class ruthenium-based chemotherapeutic agent BOLD-100 (formerly IT-139, NKP-1339, KP1339) is currently the subject of clinical evaluation for the treatment of gastric, pancreatic, colorectal and bile duct cancer.
Thomas L. Mindt, Nicholas P. Van der Meulen, Katarína Benčurová, Marcus Hacker, Wolfgang Kandioller, Barbara Happl, Zeynep Talip, Alexander Voegele, Petra Heffeter, Markus Mitterhauser, Bernhard K. Keppler, Theresa Balber, Marie Brandt   +12 more
core   +1 more source

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

Disease Models & Mechanisms, 2014
The current preclinical pipeline for drug discovery can be cumbersome and costly, which limits the number of compounds that can effectively be transitioned to use as therapies.
Chansey J. Veinotte, Graham Dellaire, Jason N. Berman   +2 more
doaj   +1 more source

Preclinical evaluation of drugs to block inflammation-driven preterm birth [PDF]

Innate Immunity, 2016
Intrauterine inflammation, the major cause of early preterm birth, can have microbial and sterile aetiologies. We assessed in a Transwell model the anti-inflammatory efficacies of five drugs on human extraplacental membranes delivered after preterm spontaneous labour (30–34 wk). Drugs [TPCA1 (IKKβ inhibitor), 5 z-7-oxozeaenol (OxZ,
Demelza J, Ireland, Elizabeth A, Nathan, Shaofu, Li, Adrian K, Charles, Lisa F, Stinson, Matthew W, Kemp, John P, Newnham, Jeffrey A, Keelan   +7 more
openaire   +2 more sources

A Breath of Fresh Air? Firm Type, Scale, Scope, and Selection Effects in Drug Development [PDF]

, 2009
This paper compares the innovation performance of established pharmaceutical firms and biotech companies, controlling for differences in the scale and scope of research.
Alfonso Gambardella, Pammolli, Fabio, Gambardella, Alfonso, Magazzini, Laura, Fabio Pammolli, F. Pammolli, A. Arora, Ashish Arora, Laura Magazzini, L. Magazzini, Arora, Ashish   +10 more
core   +1 more source

Replacement, Reduction, and Refinement of Animal Experiments in Anticancer Drug Development: The Contribution of 3D In Vitro Cancer Models in the Drug Efficacy Assessment

Biomedicines, 2023
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold standards in the preclinical assessment of anticancer drug efficacy. 3D in vitro
Elena M. Tosca, Davide Ronchi, Daniele Facciolo, Paolo Magni   +3 more
doaj   +1 more source