Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation [PDF]
Pharmaceutics, 2022 Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but also contributes to the high morbidity and mortality rates of cardiovascular diseases. Comprehensive testing for proarrhythmic risks of drugs has been applied in
Xiaoli Tang +3 more
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Advances in preclinical evaluation of experimental antibody-drug conjugates [PDF]
Cancer Drug Resistance, 2021 The ability to chemically modify monoclonal antibodies with the attachment of specific functional groups has opened up an enormous range of possibilities for the targeted treatment and diagnosis of cancer in the clinic. As the number of such antibody-based drug candidates has increased, so too has the need for more stringent and robust preclinical ...
Lyons, Scott K. +2 more
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Comparative evaluation of recommendations for preclinical studies of transporter-mediated drug–drug interactions [PDF]
Регуляторные исследования и экспертиза лекарственных средств, 2023 Scientific relevance. Sound recommendations for preclinical studies of transporter- mediated pharmacokinetic interactions of medicinal products can help increase the likelihood of identifying potentially nephrotoxic and hepatotoxic medicinal products at ...
V. A. Evteev +3 more
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EXPERT EVALUATION OF PRECLINICAL STUDIES OF PRIMARY AND SECONDARY PHARMACODYNAMICS OF MEDICINES [PDF]
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article dwells upon the results of comparative analysis of the Russian national requirements and EAEU regulations dealing with evaluation of preclinical pharmacological studies.
G. N. Engalycheva +3 more
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Disease modeling and drug screening using human airway organoids: a systematic review [PDF]
Organoid, 2021 Increasing levels of fine environmental dust particles due to industrialization and emerging respiratory illnesses, such as coronavirus disease 2019, pose serious threats to human life.
Do Hyun Kim, Sung Won Kim
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Frontiers in Pharmacology, 2021 Huntington’s disease (HD) is a life-threatening neurodegenerative disorder. Altered levels and functions of the purinergic ionotropic P2X7 receptors (P2X7Rs) have been found in animal and cellular models of HD, suggesting their possible role in the ...
Alberto Martire +5 more
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Food and Agricultural Immunology, 2021 Emerging evidence indicates that blood–retinal barrier (BRB) damage is the main cause of diabetic retinopathy (DR), and the downregulation of tight proteins (TJs) located between endothelial cells and the activation of NLRP3 inflammasome-mediated ...
Jing Wei +8 more
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Supplementary Data from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing Tumors [PDF]
, 2022 Supplementary Data from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing ...
Jeff Hooley (15084369) +30 more
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Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing Tumors [PDF]
, 2022 Supplementary Figure from Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody–drug Conjugate Targeting ADAM9-expressing ...
Jeff Hooley (15084369) +30 more
core +1 more source
Application of Genomics in Preclinical Drug Safety Evaluation [PDF]
Basic & Clinical Pharmacology & Toxicology, 2006 Abstract: Understanding the response of biological systems to xenobiotics is fundamental to the evaluation of drug safety. Toxicologists have traditionally gathered pathological, morphological, chemical and biochemical information from in vivo studies of preclinical species in order to assess drug safety and to determine how new drugs can be safely ...
Peter G, Lord +2 more
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