Results 21 to 30 of about 192,321 (311)

A Novel Human Multi-Tissue System For Preclinical Drug Evaluation And Recapitulation Of Metastasis [PDF]

, 2022
The drug development process, especially for anti-cancer therapies, continues to be highly inefficient. The current preclinical drug evaluation paradigm of human monolayer in vitro culture followed by small animal in vivo models results in a roughly 90 ...
Chramiec, Alan
core   +2 more sources

In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity

Frontiers in Pharmacology, 2022
Many medicinal plants species from European -such as Artemisia absinthium, Equisetum arvense, Lamium album, Malva sylvestris, Morus nigra, Passiflora incarnata, Frangula purshiana, and Salix alba- as well as Latin American traditions -such as Libidibia ...
Andre Luis Dias Araujo Mazzari, Mariella Guimarães Lacerda, Flora Aparecida Milton, Flora Aparecida Milton, João Augusto Mulin Montechiari Machado, Simone Batista Pires Sinoti, Anne-Soulene Toullec, Patricia Marquez Rodrigues, Francisco de Assis Rocha Neves, Luiz Alberto Simeoni, Dâmaris Silveira, Jose Maria Prieto, Jose Maria Prieto, Jose Maria Prieto   +13 more
doaj   +1 more source

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
zur Stadt, Udo, Groiss, Volker, Schneider, Katja, Renier J Brentjens, Nadia Terziyska, Harald Ehrhardt, Jeremias, I., Brentjens, Renier J., Farkasova, K., Katja Schneider, Volker Groiss (106787), Katarina Farkasova (106794), Ehrhardt, Harald, Wagner, E., Renier J. Brentjens (106801), Quintanilla-Martinez, Leticia, Martin Horstmann (45040), Ehrhardt, H., Ernst Wagner (60760), Wagner, Ernst, Leticia Quintanilla-Martinez (33277), Terziyska, N., Katja Schneider (106791), Horstmann, M., Brentjens, R.J., Catarina Castro Alves, Quintanilla-Martinez, L., Zur Stadt, U., Horstmann, Martin, Schneider, K., Ogris, M., Manfred Ogris, Alves, C.C., Nadia Terziyska (106777), Terziyska, Nadia, Jeremias, Irmela, Groiss, V., Irmela Jeremias (106806), Volker Groiss, Udo zur Stadt, Martin Horstmann, Farkasova, Katarina, Ernst Wagner, Irmela Jeremias, Ogris, Manfred, Udo zur Stadt (106803), Catarina Castro Alves (106783), Manfred Ogris (60759), Castro Alves, Catarina, Katarina Farkasova, Leticia Quintanilla-Martinez, Harald Ehrhardt (106798)   +51 more
core   +1 more source

Combination therapy with bevacizumab and a CCR2 inhibitor for human ovarian cancer: An in vivo validation study

Cancer Medicine, 2023
Background Anti‐angiogenic therapy with bevacizumab (BEV), an anti‐VEGF antibody, plays a critical role in the treatment of ovarian cancer. However, despite an encouraging initial response, most tumors become resistant to BEV over time, and a new ...
Tianyue Zhai, Takashi Mitamura, Lei Wang, Shimpei I. Kubota, Masaaki Murakami, Shinya Tanaka, Hidemichi Watari   +6 more
doaj   +1 more source

The effect of excipients on pharmacokinetic parameters of parenteral drugs [PDF]

, 2005
In the pharmaceutical industry, the main goal of early phase in vivo studies is to assess pharmacokinetic properties of a compound in laboratory animals. These data provide a basis for selecting and optimizing drug candidates.
Egger-Heigold, Barbara
core   +1 more source

Drug-Homogeneity Index in Mass-Spectrometry Imaging [PDF]

, 2018
Enhancing drug penetration in solid tumors is an interesting clinical issue of considerable importance. In preclinical research, mass-spectrometry imaging is a promising technique for visualizing drug distribution in tumors under different treatment ...
Francesca Falcetta (473387), Raffaella Giavazzi (64690), Mridula Prasad (5945189), Maurizio D’Incalci (450199), Lavinia Morosi, Mridula Prasad, Geert Postma (403504), Lavinia Morosi (450194), Pietro Franceschi (1669249), Francesca Falcetta, Raffaella Giavazzi, Enrico Davoli, Geert Postma, Jeroen Jansen (577662), Pietro Franceschi, Silvia Giordano (50663), Jeroen Jansen, Enrico Davoli (450200), Maurizio D’Incalci, Silvia Giordano   +19 more
core   +3 more sources

A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

Chinese Medicine, 2021
Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China.
Qiaofeng Li, Taijin Lan, Songhua He, Weiwei Chen, Xiaolan Li, Weiquan Zhang, Ying Liu, Qiuping Zhang, Xin Chen, Yaoyao Han, Zhiheng Su, Dan Zhu, Hongwei Guo   +12 more
doaj   +1 more source

Characterization of phototoxicity reactions in human and animal skin models [PDF]

, 2013
Phototoxicity is a relatively common phenomenon and is an adverse effect of some systemic drugs. A large number of pharmaceutical drug substances are known to carry the potential to elicit a phototoxic response (Moore 2002, Ferguson 2002). Reported cases
Boudon, Stéphanie
core   +1 more source

Complement activation as a bioequivalence issue relevant to the development of generic liposomes and other nanoparticulate drugs [PDF]

, 2015
Liposomes are known to activate the complement (C) system, which can lead in vivo to a hypersensitivity syndrome called C activation-related pseudoallergy (CARPA). CARPA has been getting increasing attention as a safety risk of i.v.
Pharmaceutics, Sub Drug targeting, Storm, G, Szebeni, Janos   +3 more
core   +1 more source

Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]

, 2014
A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core   +1 more source