Results 91 to 100 of about 19,912,299 (390)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Out‐of‐Distribution Detection as a Risk‐Control Strategy for Medical Classification Machine Learning Models

Clinical and Translational Science
Recent advances in artificial intelligence (AI) and machine learning (ML) algorithms have significantly broadened the scope in which these algorithms are deployed.
Chu Weng, Joshua Ward, Wesley Lin, Sherry Dong, Qi Liu, Hanrui Zhang   +5 more
doaj   +1 more source

The Effectiveness of Intravenous Admixture Training in a Private Hospital in Surabaya [PDF]

, 2012
In this hospital, the nurses face intravenous (iv) admixture problems in preparing and delivering iv injection and/or infusion to patients due to their limited background knowledge of drug stability and incompatibility.
Herawati, Fauna
core  

Immunovirological outcomes and resistance patterns at 4 years of antiretroviral therapy use in HIV-infected patients in Cambodia [PDF]

, 2011
Objectives  To report immunovirological outcomes and resistance patterns in adults treated with triple combination antiretroviral therapy (cART) for 4 years in an HIV programme of Phnom Penh, Cambodia.
Balkan, Suna, Chanchhaya, Ngeth, Ferradini, Laurent, Narom, Prak, Nerrienet, Eric, Pujades-Rodríguez, Mar, Schramm, Birgit, Som, Leakena   +7 more
core   +2 more sources

Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation

European Respiratory Journal, 2013
Research into the pathogenesis underlying the development of idiopathic pulmonary fibrosis is hampered by a repertoire of animal models that fail to recapitulate all the features of the human disease.
C. Scotton, Brian Hayes, R. Alexander, Arnab Datta, E. Forty, P. Mercer, A. Blanchard, R. Chambers   +7 more
semanticscholar   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Monitoring of veterinary drug residues in livestock products with antimicrobial resistance

Applied Biological Chemistry
Antimicrobial resistance (AMR) in animal-derived products remains a global concern, while reports on veterinary drug (VD) residues in such products are relatively rare.
Dahae Park, Yu Ra Kim, Ji Young Kim, Jang-Duck Choi, Guiim Moon, Dong Woo Shin   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A network of regulatory innovations to improve FDA quality assessments of human drug applications

International Journal of Pharmaceutics: X
A network of regulatory innovations brings a holistic approach to improving the submission, assessment, and lifecycle management of pharmaceutical quality information in the U.S. This dedicated effort in the FDA’s Center for Drug Evaluation and Research (
Russie Tran, Grace Fraser, Adam C. Fisher, Sau L. Lee, Ashley Boam, Stelios Tsinontides, Jennifer Maguire, Lawrence X. Yu, Susan Rosencrance, Steven Kozlowski, Don Henry   +10 more
doaj   +1 more source

Clinical guidelines for managing hearing loss as a complication of drug-resistant tuberculosis treatment: an evaluation of implementation fidelity in Kano, Nigeria [PDF]

, 2022
Sani Ibrahim Muhammad, Ejemai Eboreime, Vivian Ifeoma Ogbonna, Iliyasu Zubairu, Latifat Ibisomi   +4 more
openalex   +1 more source