Results 121 to 130 of about 18,950,887 (401)
Modeling long-term longitudinal HIV dynamics with application to an AIDS clinical study
, 2009 A virologic marker, the number of HIV RNA copies or viral load, is currently used to evaluate antiretroviral (ARV) therapies in AIDS clinical trials. This marker can be used to assess the ARV potency of therapies, but is easily affected by drug exposures,
Huang, Yangxin, Lu, Tao
core +1 more source
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
FDA’s new pharmaceutical quality initiative: Knowledge-aided assessment & structured applications
International Journal of Pharmaceutics: X, 2019 This paper describes a new FDA’s pharmaceutical quality assessment system: Knowledge-aided Assessment & Structured Application (KASA). The KASA system is designed to: 1) capture and manage knowledge during the lifecycle of a drug product; 2) establish ...
Lawrence X. Yu +5 more
doaj
Characterization of heme binding to recombinant α1-microglobulin
Frontiers in Physiology, 2014 Background: Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identified as a heme and radical scavenger that may participate in the mitigation of toxicities caused by degradation of hemoglobin.
Elena eKarnaukhova +5 more
doaj +1 more source
THE EVALUATION OF ANALGESIC POTENCY OF DRUGS USING THERMAL STIMULATION IN THE RAT [PDF]
, 1952 H. Jackson
openalex +1 more source
Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance
Molecular Oncology, EarlyView.In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang +8 more
wiley +1 more source
CPT: Pharmacometrics & Systems PharmacologyThe number of quantitative systems pharmacology (QSP) submissions to the U.S. Food and Drug Administration has continued to increase over the past decade. This report summarizes the landscape of QSP submissions as of December 2023. QSP was used to inform
Jane P. F. Bai +10 more
doaj +1 more source
Cancer Medicine, 2019 Several epidemiological studies have found an association between maternal antibiotics use during pregnancy and increased risk of certain cancer types, although conclusions differ between studies.
Xibiao Ye +3 more
doaj +1 more source
Application of morbid animal model in drug safety evaluation of TCM
Frontiers in Pharmacology, 2015 Further toxicology research of TCM new drugs is still necessary in animals. In some cases, it is necessary to pay more attention to the use of morbid animals in pre-clinical safety research in despite of some deficiencies.
Ning eKe-Yong, Li eMin
doaj +1 more source