Results 151 to 160 of about 1,122,477 (316)

Animal models for evaluating psychotropic drugs [PDF]

, 1974
Ramesh Kumar
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Manufacturing Uniform Cerebral Organoids for Neurological Disease Modeling and Drug Evaluation. [PDF]

Biomater Res
Hong H, Jun Y, Yoon SB, Park S, Lee J, Jang JW, Nam HJ, Cho H.   +7 more
europepmc   +1 more source

A SCORING SYSTEM FOR ABSTINENCE SYNDROME IN MORPHINE DEPENDENT MICE AND APPLICATION TO EVALUATE MORPHINE TYPE DEPENDENCE LIABILITY OF DRUGS

, 1973
Hiroshi Kaneto, Masao Koida, H Nakanishi, Hiroshi Sasano   +3 more
openalex   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Bioprinting of a multi-composition array to mimic intra-tumor heterogeneity of glioblastoma for drug evaluation. [PDF]

Microsyst Nanoeng
Lee G, Kim SJ, Choi Y, Park J, Park JK.
europepmc   +1 more source

The Application of Enzyme Histochemistry To Drug Safety Evaluation [PDF]

, 1973
H Kief, K. Engelbart
openalex   +1 more source

The Evaluation of New Drugs

Journal of Pharmacy and Pharmacology, 1958
Leonard G Goodwin, Frank L Rose
openaire   +3 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model. [PDF]

Inflamm Regen
Nishidate A, Takemoto K, Imura Y, Murase M, Yamanaka R, Kikuchi M, Anan J, Kato S, Akatsuka A, Mochizuki S, Koda Y.   +10 more
europepmc   +1 more source