Results 181 to 190 of about 1,122,477 (316)

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

open access: yesMolecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Primary biliary cholangitis drug evaluation and regulatory approval: Where do we go from here? [PDF]

open access: yesHepatology
Jones DEJ   +24 more
europepmc   +1 more source

Suitability of external controls for drug evaluation in Duchenne muscular dystrophy. [PDF]

open access: yesNeurology, 2020
Goemans N   +13 more
europepmc   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

open access: yesMolecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella   +18 more
wiley   +1 more source

Evaluation of Drug-Drug Interactions in Drug Development.

open access: yesRinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 2003
Dipti M. Amin, Jean-Pierre Isal
openaire   +3 more sources

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