Results 181 to 190 of about 18,950,887 (401)

Expanded Access of Investigational Drugs: The Experience of the Center of Drug Evaluation and Research Over a 10-Year Period

Therapeutic Innovation and Regulatory Science, 2016
J. Jarow, S. Lemery, Kevin Bugin, S. Khozin, R. Moscicki   +4 more
semanticscholar   +1 more source

A Bioprinted Heart-on-a-Chip with Human Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Evaluation. [PDF]

Bioengineering (Basel), 2022
Faulkner-Jones A, Zamora V, Hortigon-Vinagre MP, Wang W, Ardron M, Smith GL, Shu W.   +6 more
europepmc   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Evaluation of Blackhead Preventive Drugs with Regard to Growth and Feed Efficiency of Turkeys

, 1967
Richard L. Atkinson, J.W. Bradley, J.R. Couch, J.H. Quisenberry   +3 more
openalex   +1 more source

Drug Evaluation Based on a Multi-Channel Cell Chip with a Horizontal Co-Culture. [PDF]

Int J Mol Sci, 2021
Kim GJ, Lee KJ, Choi JW, An JH.
europepmc   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

THE CLINICAL EVALUATION OF NARCOTIC AND SEDATWE DRUGS I: INTRODUCTION

, 1965
David G. Campbell, A.H.B. MASSON, Walter Norris   +2 more
openalex   +1 more source

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Nature Metabolism, 2020
L. Folkersen, S. Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Å. Hedman, A. Schork, K. Page, D. Zhernakova, Yang Wu, J. Peters, N. Eriksson, Sarah L Bergen, Thibaud S. Boutin, A. Bretherick, Stefan Enroth, A. Kalnapenkis, J. Gådin, B. Suur, Yan Chen, L. Matic, J. Gale, Julie Lee, Weidong Zhang, A. Quazi, M. Ala-Korpela, S. Choi, A. Claringbould, J. Danesh, G. Davey Smith, Federico De Masi, S. Elmståhl, G. Engström, E. Fauman, C. Fernandez, L. Franke, P. Franks, V. Giedraitis, C. Haley, A. Hamsten, A. Ingason, Å. Johansson, Peter K. Joshi, L. Lind, C. Lindgren, S. Lubitz, T. Palmer, E. Macdonald-Dunlop, M. Magnusson, O. Melander, K. Michaelsson, A. Morris, R. Mägi, Michael W. Nagle, P. Nilsson, J. Nilsson, M. Orho-Melander, O. Polašek, B. Prins, E. Pålsson, Ting Qi, M. Sjögren, J. Sundström, P. Surendran, U. Võsa, T. Werge, Rasmus Wernersson, H. Westra, Jian Yang, A. Zhernakova, J. Ärnlöv, Jingyuan Fu, J. Smith, T. Esko, C. Hayward, U. Gyllensten, M. Landén, A. Siegbahn, James F. Wilson, L. Wallentin, A. Butterworth, M. Holmes, E. Ingelsson, A. Mälarstig   +82 more
semanticscholar   +1 more source

Production of a New Drug: A Sequential Investment ProcessUnder Uncertainty [PDF]

On the basis of a database of more than 80 thousand records on total retails and production costs of the pharmaceutical industry worldwide we consider four classes of drugs.
Carlo Zappia, Marcello Basili, Roberto Renò   +2 more
core  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source