Results 181 to 190 of about 19,912,299 (390)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Human umbilical cord mesenchymal stem cell therapy for atopic dermatitis through inhibition of neutrophil chemotaxis

Stem Cell Research & Therapy
Background Atopic dermatitis (AD) management is significantly challenging due to the high prevalence, chronicity, and recurrent nature of the disease, and limited options for its treatment.
Jinjin Shao, Zhiqi Xie, Zhichao Ye, Guoyu Chen, Yiru Wang, Lili Zhang, Fang Liu, Siming Zhang, Xiaobo Lin, Jiahong Wang, Ying Chen, Yunxiang Chen, Xin Pan, Feifei Wu, Ruolang Pan, Jinfeng Liang, Lijiang Zhang   +16 more
doaj   +1 more source

Live-cell imaging-based dynamic vascular formation assay for antivascular drug evaluation and screening. [PDF]

iScience, 2023
Li Z, Zhang H, Sun Y, Feng Z, Cui B, Han J, Li Y, Liu H, Sun T.   +8 more
europepmc   +1 more source

Optimal Medical Therapy With or Without Percutaneous Coronary Intervention to Reduce Ischemic Burden: Results From the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) Trial Nuclear Substudy

Circulation, 2008
L. Shaw, D. Berman, D. Maron, G. Mancini, S. Hayes, P. Hartigan, W. Weintraub, R. O'rourke, Marcin Dada, J. Spertus, B. Chaitman, J. Friedman, P. Slomka, G. Heller, G. Germano, G. Gosselin, P. Berger, W. Kostuk, R. Schwartz, M. Knudtson, E. Veledar, E. Bates, B. Mccallister, K. Teo, W. Boden   +24 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Human Metastatic Cholangiocarcinoma Patient-Derived Xenografts and Tumoroids for Preclinical Drug Evaluation. [PDF]

Clin Cancer Res, 2023
Serra-Camprubí Q, Verdaguer H, Oliveros W, Lupión-Garcia N, Llop-Guevara A, Molina C, Vila-Casadesús M, Turpin A, Neuzillet C, Frigola J, Querol J, Yáñez-Bartolomé M, Castet F, Fabregat-Franco C, Escudero-Iriarte C, Escorihuela M, Arenas EJ, Bernadó-Morales C, Haro N, Giles FJ, Pozo ÓJ, Miquel JM, Nuciforo PG, Vivancos A, Melé M, Serra V, Arribas J, Tabernero J, Peiró S, Macarulla T, Tian TV.   +30 more
europepmc   +1 more source

Evaluation of mAb 2C5-modified dendrimer-based micelles for the co-delivery of siRNA and chemotherapeutic drug in xenograft mice model [PDF]

Satya Siva Kishan Yalamarty, Nina Filipczak, Tanvi Vinod Pathrikar, Colin Cotter, Janaína Artem Ataide, Ed Luther, Swarali Paranjape, Vladimir P. Torchilin   +7 more
openalex   +1 more source

Expanded Access of Investigational Drugs: The Experience of the Center of Drug Evaluation and Research Over a 10-Year Period

Therapeutic Innovation and Regulatory Science, 2016
J. Jarow, S. Lemery, Kevin Bugin, S. Khozin, R. Moscicki   +4 more
semanticscholar   +1 more source

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Nature Metabolism, 2020
L. Folkersen, S. Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Å. Hedman, A. Schork, K. Page, D. Zhernakova, Yang Wu, J. Peters, N. Eriksson, Sarah L Bergen, Thibaud S. Boutin, A. Bretherick, Stefan Enroth, A. Kalnapenkis, J. Gådin, B. Suur, Yan Chen, L. Matic, J. Gale, Julie Lee, Weidong Zhang, A. Quazi, M. Ala-Korpela, S. Choi, A. Claringbould, J. Danesh, G. Davey Smith, Federico De Masi, S. Elmståhl, G. Engström, E. Fauman, C. Fernandez, L. Franke, P. Franks, V. Giedraitis, C. Haley, A. Hamsten, A. Ingason, Å. Johansson, Peter K. Joshi, L. Lind, C. Lindgren, S. Lubitz, T. Palmer, E. Macdonald-Dunlop, M. Magnusson, O. Melander, K. Michaelsson, A. Morris, R. Mägi, Michael W. Nagle, P. Nilsson, J. Nilsson, M. Orho-Melander, O. Polašek, B. Prins, E. Pålsson, Ting Qi, M. Sjögren, J. Sundström, P. Surendran, U. Võsa, T. Werge, Rasmus Wernersson, H. Westra, Jian Yang, A. Zhernakova, J. Ärnlöv, Jingyuan Fu, J. Smith, T. Esko, C. Hayward, U. Gyllensten, M. Landén, A. Siegbahn, James F. Wilson, L. Wallentin, A. Butterworth, M. Holmes, E. Ingelsson, A. Mälarstig   +82 more
semanticscholar   +1 more source