Results 271 to 280 of about 18,950,887 (401)
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
The evaluation of different types of anti‐convulsant drug activity against leptazol‐induced epileptogenic activity in the anaesthetized rat [PDF]
, 1983 Ashley Kent, R.A. Webster
openalex +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation. [PDF]
Biophys J, 2020 Paci M +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
CLINICAL EVALUATION OF DRUG EFTICACY BY THE DOUBLE BLIND METHOD IN MEDICINE
, 1976 N Shimizu
openalex +2 more sources
Apixaban in a Morbid Obese Patient with Atrial Fibrillation: A Clinical Experience Using the Plasmatic Drug Evaluation. [PDF]
J Blood Med, 2020 Russo V +10 more
europepmc +1 more source
Beyond Drug Regulation: The Science of Drug Evaluation [PDF]
Molecular Medicine, 1996 openaire +3 more sources