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EVALUATION OF ANTIEPILEPTIC DRUGS

Archives of Neurology And Psychiatry, 1950
TWO PRINCIPAL electric shock methods have been employed for the laboratory appraisal of anticonvulsant drugs: ( a ) the method of Putnam and Merritt 1 and ( b ) that of Toman, Swinyard and Goodman. 2 In the former, the anticonvulsant potency of a compound is determined by its ability to raise the electric shock convulsion threshold in the cat ...
Graham Chen, Charles R. Ensor
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Microfluidics for Drug Development: From Synthesis to Evaluation.

Chemical Reviews, 2021
Drug development is a long process whose main content includes drug synthesis, drug delivery, and drug evaluation. Compared with conventional drug development procedures, microfluidics has emerged as a revolutionary technology in that it offers a ...
Yuxiao Liu   +4 more
semanticscholar   +1 more source

The evaluation of antirheumatic drugs

Current Medical Research and Opinion, 1973
SummaryThe available methods of evaluation of an antirheumatic compound in a clinical trial situation are discussed. The techniques of single-blind and double-blind studies are described and their respective merits analysed. Proposed new techniques for the measurement of joint inflammation are reviewed.
W. C. Dick   +3 more
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Plasmonic Nanohole Sensor for Capturing Single Virus-Like Particles toward Virucidal Drug Evaluation.

Small, 2016
A plasmonic nanohole sensor for virus-like particle capture and virucidal drug evaluation is reported. Using a materials-selective surface functionalization scheme, passive immobilization of virus-like particles only within the nanoholes is achieved. The
Joshua A. Jackman   +8 more
semanticscholar   +1 more source

Drug evaluation review: dupilumab in atopic dermatitis.

Immunotherapy, 2015
Atopic dermatitis (AD) is characterized by type 2 helper T (Th2) cell-driven inflammation. Dupilumab is a fully human monoclonal antibody directed against the IL-4 receptor α subunit that blocks the signaling of IL-4 and IL-13, both key cytokines in Th2 ...
J. Hamilton   +2 more
semanticscholar   +1 more source

The evaluation of cytotoxic drugs

Cancer Treatment Reviews, 1979
SCOPUS: ar.j ; info:eu-repo/semantics ...
Von Hoff, Daniel D.D.   +2 more
openaire   +3 more sources

Chronic myeloid leukemia drug evaluation using a multisignal amplified photoelectrochemical sensing platform.

Analytical Chemistry, 2014
Chronic myeloid leukemia (CML) is a malignant clone disease of hematopoietic stem cells. At present, the most effective therapy for CML is bone marrow transplantation, but this procedure is expensive, and it is often difficult to find appropriately ...
Shiwei Zhou   +5 more
semanticscholar   +1 more source

AMA Drug Evaluations

JAMA: The Journal of the American Medical Association, 1977
The third edition of the AMA Drug Evaluations book ( ADE ) has just been published. * The first edition that appeared in 1971 was prepared by the American Medical Association Department of Drugs under the direction of the Association's Council on Drugs.
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Evaluation of Drugs

Archives of Otolaryngology - Head and Neck Surgery, 1962
The clinical trial of drugs is of the greatest importance in improving medical practice. No matter how carefully a drug may be studied chemically, in tissue culture, or in lower animals, the final test of its efficacy must be made in human beings. Physicians are constantly called upon by drug companies to conduct such trials.
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EVALUATION OF DRUGS

Journal of the American Medical Association, 1958
To the Editor:— The article, "Factors Influencing Clinical Evaluation of Drugs," by Modell and Houde, inThe Journal( 167: 2190-2199 [Aug. 30] 1958) was most interesting and important. However, a most significant factor in the appraisal of drugs should be mentioned in this connection, and that is timing.
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