Results 31 to 40 of about 19,912,299 (390)
Nature Communications, 2019 Hepatitis delta virus (HDV) depends on the helper function of hepatitis B virus (HBV), which provides the envelope proteins for progeny virus secretion. Current infection-competent cell culture models do not support assembly and secretion of HDV.
Florian A. Lempp +7 more
semanticscholar +1 more source
Community sewage sensors towards evaluation of drug use trends: detection of cocaine in wastewater with DNA-directed immobilization aptamer sensors [PDF]
, 2016 Illicit drug use has a global concern and effective monitoring and interventions are highly required to combat drug abuse. Wastewater-based epidemiology (WBE) is an innovative and cost-effective approach to evaluate community-wide drug use trends ...
Castrignanò, Erika +4 more
core +1 more source
Ceftobiprole: drug evaluation and place in therapy
Expert Review of Anti-Infective Therapy, 2019 Introduction: Ceftobiprole is a fifth-generation cephalosporin with a broad spectrum of antimicrobial activity, including also methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole is approved for the treatment of community-acquired pneumonia (
D. Giacobbe +10 more
semanticscholar +1 more source
Virology Journal, 2019 Background Conventional assays to titrate polioviruses usually test serial dilutions inoculated into replicate cell cultures to determine a 50% cytopathic endpoint, a process that is both time-consuming and laborious.
Hasmik Manukyan +5 more
doaj +1 more source
Target-based evaluation of ‘drug-like’ properties and ligand efficiencies
Journal of Medicinal Chemistry, 2021 Physicochemical descriptors commonly used to define ‘drug-likeness’, and ligand efficiency measures, are assessed for their ability to differentiate marketed drugs from compounds reported to bind to their efficacious target or targets.
P. Leeson +6 more
semanticscholar +1 more source
Dose-finding studies in drug development for rare genetic diseases
Orphanet Journal of Rare Diseases, 2022 Background The small patient populations inherent to rare genetic diseases present many challenges to the traditional drug development paradigm. One major challenge is generating sufficient data in early phase studies to inform dose selection for later ...
Lingshan Wang +6 more
doaj +1 more source
Towards a transparent, credible, evidence-based decision-making process of new drug listing on the Hong Kong Hospital Authority Drug Formulary: challenges and suggestions [PDF]
, 2017 The aim of this article is to describe the process, evaluation criteria, and possible outcomes of decision-making for new drugs listed in the Hong Kong Hospital Authority Drug Formulary in comparison to the health technology assessment (HTA) policy ...
Cheung, Bernard M.Y. +2 more
core +2 more sources
Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles [PDF]
, 2004 The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles as carrier systems for doxorubicin (Dox). Transferrin (Tf) was covalently bound to the Dox-loaded palmitoylated glycol chitosan (GCP) vesicles using ...
Couet, William +5 more
core +1 more source
Organotypic brain explant culture as a drug evaluation system for malignant brain tumors
Cancer Medicine, 2017 Therapeutic options for malignant brain tumors are limited, with new drugs being continuously evaluated. Organotypic brain slice culture has been adopted for neuroscience studies as a system that preserves brain architecture, cellular function, and the ...
N. Minami +11 more
semanticscholar +1 more source
, 2012 Background. Drug-drug interaction (DDI) is a major cause of morbidity and mortality. [...] Biomedical literature mining can aid DDI research by extracting relevant DDI signals from either the published literature or large clinical databases.
Kolchinsky, Artemy +3 more
core +1 more source