Results 31 to 40 of about 18,950,887 (401)
Dose-finding studies in drug development for rare genetic diseases
Orphanet Journal of Rare Diseases, 2022 Background The small patient populations inherent to rare genetic diseases present many challenges to the traditional drug development paradigm. One major challenge is generating sufficient data in early phase studies to inform dose selection for later ...
Lingshan Wang +6 more
doaj +1 more source
Advanced therapy medicinal products in China: Regulation and development
MedComm, 2023 Advanced therapy medicinal products (ATMPs) have shown dramatic efficacy in addressing serious diseases over the past decade. With the acceleration and deepening of China's drug regulatory reforms, the country sees a continuous introduction of policies ...
Jiaqi Lu, Longchang Xu, Wei Wei, Wu He
doaj +1 more source
Virology Journal, 2019 Background Conventional assays to titrate polioviruses usually test serial dilutions inoculated into replicate cell cultures to determine a 50% cytopathic endpoint, a process that is both time-consuming and laborious.
Hasmik Manukyan +5 more
doaj +1 more source
Organotypic brain explant culture as a drug evaluation system for malignant brain tumors
Cancer Medicine, 2017 Therapeutic options for malignant brain tumors are limited, with new drugs being continuously evaluated. Organotypic brain slice culture has been adopted for neuroscience studies as a system that preserves brain architecture, cellular function, and the ...
N. Minami +11 more
semanticscholar +1 more source
Cancer Cell International, 2019 Background DKK1 has been reported to act as a tumor suppressor in breast cancer. However, the mechanism of DKK1 inhibits breast cancer migration and invasion was still unclear.
Jie Niu +9 more
doaj +1 more source
npj Vaccines, 2021 Numerous vaccine candidates against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are under development. The majority of vaccine candidates to date are designed to induce immune responses against the viral spike (S) protein, although ...
Clement A. Meseda +8 more
doaj +1 more source
Comparison of commonly used ICR stocks and the characterization of Korl:ICR
Laboratory Animal Research, 2017 Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. Outbred mouse stocks, are used in toxicology, oncology, infection and pharmacology research.
Hye-Jun Shin +7 more
doaj +1 more source
Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques
Pharmaceutics, 2020 Owing to their tunable properties, controllable degradation, and ability to protect labile drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a lack of standardized methodologies used to characterize and evaluate drug
Margaux Vigata +3 more
semanticscholar +1 more source
BMC Biology, 2012 There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo microenvironment than simple two-dimensional cell monolayers, not least with respect to gene expression profiles, signaling ...
M. Vinci +9 more
semanticscholar +1 more source
Evaluating the Relevance of Virtual Drugs
, 2022 Information about drugs is numerous and varied, and many drugs can share the same information. Grouping drugs that have common characteristics can be useful to avoid redundancy and facilitate interoperability. Our work focused on the evaluation of the relevance of classes allowing this type of grouping: the “Virtual Drug”.
Awuklu, Yvon K. +5 more
openaire +4 more sources