Results 21 to 30 of about 2,624,672 (298)

Geriatric pharmacotherapy : optimisation through integrated approach in the hospital setting [PDF]

, 2016
Since older patients are more vulnerable to adverse drug-related events, there is a need to ensure appropriate prescribing in these patients in order to prevent misuse, overuse and underuse of drugs.
A Corsonello, A Jha, A Leendertse, A Somers, A Somers, A Somers, A Spinewine, A Spinewine, A Spinewine, American Geriatrics Society, B Basger, B Berenguer, B Lund, B Strom, B Tangiisuran, C Lindley, C Naugler, C Rancourt, C Scullin, C Zhan, D Classen, E Hajjar, G Batty, G Ellis, G Onder, G Onder, G Onder, G Onder, H Beijer, H Hamilton, I Eland, J Hanlon, J Hanlon, J Klopotowska, J Lazarou, J Schnipper, J Wolfstadt, K Perehudoff, K Schmader, L Leape, M Beers, M Laroche, M O’Connor, M Passarelli, M Petrovic, M Petrovic, M Pirmohamed, M Steinman, NS Wenger, P Bemt van den, P Gallagher, P Gallagher, P Lampela, P McLeod, P Rochon, R Cipolle, R Page, S Holt, S Kaur, S Kucukarslan, S Rognstad, T Field, T Field, W Winit-Watjana   +63 more
core   +1 more source

Multiplex PCR-based titration (MPBT) assay for determination of infectious titers of the three Sabin strains of live poliovirus vaccine

Virology Journal, 2019
Background Conventional assays to titrate polioviruses usually test serial dilutions inoculated into replicate cell cultures to determine a 50% cytopathic endpoint, a process that is both time-consuming and laborious.
Hasmik Manukyan, Elvira Rodionova, Tatiana Zagorodnyaya, Tsai-Lien Lin, Konstantin Chumakov, Majid Laassri   +5 more
doaj   +1 more source

Dose-finding studies in drug development for rare genetic diseases

Orphanet Journal of Rare Diseases, 2022
Background The small patient populations inherent to rare genetic diseases present many challenges to the traditional drug development paradigm. One major challenge is generating sufficient data in early phase studies to inform dose selection for later ...
Lingshan Wang, Jie Wang, Ji Feng, Mary Doi, Salvatore Pepe, Michael Pacanowski, Robert N. Schuck   +6 more
doaj   +1 more source

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles [PDF]

, 2004
The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles as carrier systems for doxorubicin (Dox). Transferrin (Tf) was covalently bound to the Dox-loaded palmitoylated glycol chitosan (GCP) vesicles using ...
Couet, William, Dufès, Christine, Muller, Jean-Marc, Olivier, Jean-Christophe, Schätzlein, Andreas G., Uchegbu, I.F.   +5 more
core   +1 more source

Industry-scale application and evaluation of deep learning for drug target prediction [PDF]

, 2019
Artificial intelligence (AI) is undergoing a revolution thanks to the breakthroughs of machine learning algorithms in computer vision, speech recognition, natural language processing and generative modelling.
Ashby, Thomas J., Böhm, Stanislav, Ceulemans, Hugo, Chen, Hongming, Chupakhin, Vladimir, Cima, Vojtěch, Engkvist, Ola, Golib-Dzib, Jose-Felipe, Greene, Nigel, Hochreiter, Sepp, Jeliazkova, Nina, Klambauer, Günter, Martinovič, Jan, Mayr, Andreas, Sturm, Noe, Van, Thanh Le, Vander Aa, Tom, Vandriessche, Yves, Wegner, Joerg   +18 more
core   +2 more sources

Public feedback to FDA on regulatory considerations for AI in drug manufacturing

AAPS Open
FDA’s Center for Drug Evaluation and Research (CDER) established the Framework for Regulatory Advanced Manufacturing Evaluation (FRAME) initiative to establish a regulatory framework to support the adoption of advanced manufacturing technologies that ...
Jayanti Das, Thomas F. O’Connor, Adam C. Fisher, Manuel Osorio, Johnny Lam, Riley C. Myers   +5 more
doaj   +1 more source

Getting the best outcomes from epilepsy surgery. [PDF]

, 2018
Neurosurgery is an underutilized treatment that can potentially cure drug-refractory epilepsy. Careful, multidisciplinary presurgical evaluation is vital for selecting patients and to ensure optimal outcomes.
Duncan, John S, Elger, Christian E, Engel, Jerome, Staba, Richard, Vakharia, Vejay N, Witt, Juri-Alexander   +5 more
core  

Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment [PDF]

, 2014
Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This ‘gold standard’ has low sensitivity at low infection intensities.
A Koukounari, A Koukounari, Alan Fenwick, AP Plaisier, B Erko, BJ Vennervald, CD Criscione, CJ Standley, CM Gower, D De Clercq, D Engels, D Rollinson, David W. Oguttu, DD Lin, DG Colley, HL Shane, IM Cesari, J Utzinger, J Utzinger, J Utzinger, Joanne P. Webster, JP Webster, JR Landis, JR Stothard, JR Stothard, JS Kim, JT Coulibaly, JT Coulibaly, K Stete, L van Lieshout, L van Lieshout, LA Tchuem Tchuenté, LI Gomes, LM Siqueira, M Adriko, M Albonico, M Booth, MD French, MJ Enk, N Katz, Narcis B. Kabatereine, NB Kabatereine, PHL Lamberton, PJ Hotez, Poppy H. L. Lamberton, R Bergquist, R Grenfell, RA Ashton, RF Grenfell, RF Grenfell, S Brooker, S Knopp, S Knopp, S Knopp, SM da Frota, Stefanie Knopp, Y Zhang   +56 more
core   +5 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Quantitative analysis method for isoeugenol in fishery products using gas chromatography–tandem mass spectrometry

Applied Biological Chemistry
Isoeugenol, an anesthetic used in marine products, has different regulations in each country and there is controversy regarding the degree of risk. Therefore, it is necessary to establish reliable analytical methods for detection and quantification.
Ye-Bin Jang, Yeong-Ju Jo, Mi-ok Kim, Gui-Hyun Jang   +3 more
doaj   +1 more source