Results 21 to 30 of about 1,388,675 (309)
Laboratory Animal Research, 2020 Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established.
Nam Hee Youn +7 more
doaj +1 more source
Blood Cancer Journal, 2022 This retrospective observational study evaluated racial disparities among Black and White patients with multiple myeloma (MM). We included patients from a longitudinal de-identified EHR-derived database who had ≥2 visits recorded on or after 1/1/2011 ...
Kathleen Maignan +10 more
doaj +1 more source
Robust Sub-nanomolar Library Preparation for High Throughput Next Generation Sequencing
BMC Genomics, 2018 Background Current library preparation protocols for Illumina HiSeq and MiSeq DNA sequencers require ≥2 nM initial library for subsequent loading of denatured cDNA onto flow cells.
Wells W. Wu +7 more
doaj +1 more source
Consideration on the Research and Development of Anti-tumor Bispecific Antibody Drugs
Chinese Journal of Lung Cancer, 2022 The drugs of programmed cell death 1 and its ligand 1 immune checkpoint inhibitors have ushered in a new era of anti-tumor immunotherapy, which has shown outstanding efficacy in some tumors, such as Hodgkin lymphoma, but there is still low response rate ...
Yuanyuan SONG +4 more
doaj +1 more source
Evaluation of the Peer Support Program (Student Drug Prevention) 1986-1987
, 2019 The Peer Support program is a school based program funded by the National Campaign Against Drug Abuse (NCADA) as a drug prevention strategy. Prior to the existence of the NCADA the program was funded through the NSW Drug and Alcohol Authority.
Directorate of the Drug Offensive
core +1 more source
Virology Journal, 2019 Background Conventional assays to titrate polioviruses usually test serial dilutions inoculated into replicate cell cultures to determine a 50% cytopathic endpoint, a process that is both time-consuming and laborious.
Hasmik Manukyan +5 more
doaj +1 more source
Advanced therapy medicinal products in China: Regulation and development
MedComm, 2023 Advanced therapy medicinal products (ATMPs) have shown dramatic efficacy in addressing serious diseases over the past decade. With the acceleration and deepening of China's drug regulatory reforms, the country sees a continuous introduction of policies ...
Jiaqi Lu, Longchang Xu, Wei Wei, Wu He
doaj +1 more source
Dose-finding studies in drug development for rare genetic diseases
Orphanet Journal of Rare Diseases, 2022 Background The small patient populations inherent to rare genetic diseases present many challenges to the traditional drug development paradigm. One major challenge is generating sufficient data in early phase studies to inform dose selection for later ...
Lingshan Wang +6 more
doaj +1 more source
The in vivo revolution in CAR-T therapy medicinal products: challenges and regulatory prospects
Signal Transduction and Targeted TherapyChimeric antigen receptor T-cell (CAR-T) therapy, a groundbreaking advancement in cancer immunotherapy, has demonstrated remarkable efficacy in treating hematological malignancies and autoimmune diseases.
Jiaqi Lu +7 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source