Results 51 to 60 of about 19,912,299 (390)

Oncogenic NRAS Mutation in Incipient Sarcomatous Transformation of Cystic Nephroma From a Patient With DICER1‐Related Tumor Predisposition Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Anaplastic sarcoma of the kidney (ASK) is a DICER1‐associated malignant tumor presumed to arise in a benign precursor, pediatric cystic nephroma (PCN). However, the initial oncogenic alteration(s) associated with malignant transformation are unknown.
Nahir Cortes‐Santiago, Sarah B. Whittle, Sarah Scollon, Sharon E. Plon, Sanjeev Vasudevan, Bryony J. Lucas, Angshumoy Roy   +6 more
wiley   +1 more source

Preoperative Cytopenia in Patients Affected by High‐Risk Neuroblastoma: Just a Matter of Platelets?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims In patients affected by high‐risk neuroblastoma (HR‐NB), complete macroscopic resection (CMR) is associated with better outcomes. These patients are often cytopenic due to intensive induction regimens. The aim of the present study is to assess the impact of preoperative cytopenia on surgical outcome in patients with HR‐NB ...
Giorgio Persano, Valerio Voglino, Federico Beati, Cristina Martucci, Chiara Grimaldi, Francesca Del Bufalo, Annalisa Serra, Francesco Fabozzi, Carmen Malaspina, Pier Luigi Di Paolo, Gian Luigi Natali, Simone Reali, Maria Antonietta De Ioris, Alessandro Crocoli   +13 more
wiley   +1 more source

Geriatric pharmacotherapy : optimisation through integrated approach in the hospital setting [PDF]

, 2016
Since older patients are more vulnerable to adverse drug-related events, there is a need to ensure appropriate prescribing in these patients in order to prevent misuse, overuse and underuse of drugs.
A Corsonello, A Jha, A Leendertse, A Somers, A Somers, A Somers, A Spinewine, A Spinewine, A Spinewine, American Geriatrics Society, B Basger, B Berenguer, B Lund, B Strom, B Tangiisuran, C Lindley, C Naugler, C Rancourt, C Scullin, C Zhan, D Classen, E Hajjar, G Batty, G Ellis, G Onder, G Onder, G Onder, G Onder, H Beijer, H Hamilton, I Eland, J Hanlon, J Hanlon, J Klopotowska, J Lazarou, J Schnipper, J Wolfstadt, K Perehudoff, K Schmader, L Leape, M Beers, M Laroche, M O’Connor, M Passarelli, M Petrovic, M Petrovic, M Pirmohamed, M Steinman, NS Wenger, P Bemt van den, P Gallagher, P Gallagher, P Lampela, P McLeod, P Rochon, R Cipolle, R Page, S Holt, S Kaur, S Kucukarslan, S Rognstad, T Field, T Field, W Winit-Watjana   +63 more
core   +1 more source

What to Do When Medical Evidence Can Only Be Generated Through Routine Data: An Example From Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children undergoing allogeneic stem cell transplantation often receive off‐label rituximab treatment for Epstein–Barr virus reactivation, using adult dosing without pediatric evidence. This project aims to develop a clinical decision support tool (CDSS) that provides evidence‐based dosing scenarios by analyzing real‐world patient data.
Birgit Burkhardt, Antje Walz, Dietrich Knoerzer   +2 more
wiley   +1 more source

Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles. [PDF]

, 2012
This study presents a new multimodal imaging approach that includes high-frequency ultrasound, fluorescence intensity, confocal, and spectral imaging to improve the preclinical evaluation of new therapeutics in vivo.
Chu, David, Farkas, Daniel L, Hwang, Jae Youn, Kang, Bong Jin, Lubow, David J, Medina-Kauwe, Lali K, Park, Jinhyoung, Shung, K Kirk   +7 more
core   +7 more sources

Dual functional POGases from bacteria encompassing broader O-glycanase and adhesin activities

Nature Communications
Mucin-type O-glycans on glycoproteins are pivotal for biology and impact the quality of biotherapeutics. Furthermore, glycans on host cells serve as ligands for lectins/adhesins on bacteria for bacterium-host interactions in the colonization or ...
Linjiao Zhou, Uriel Ortega-Rodriguez, Matthew J. Flores, Yasuyuki Matsumoto, John Q. Bettinger, Wells W. Wu, Yaqin Zhang, Su-Ryun Kim, Thomas G. Biel, Jordan D. Pritts, Rong-Fong Shen, V. Ashutosh Rao, Tongzhong Ju   +12 more
doaj   +1 more source

Comparison of commonly used ICR stocks and the characterization of Korl:ICR

Laboratory Animal Research, 2017
Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. Outbred mouse stocks, are used in toxicology, oncology, infection and pharmacology research.
Hye-Jun Shin, Young Min Cho, Hee Jung Shin, Hae Deun Kim, Kyung Min Choi, Mi Gyeong Kim, Hyoung Doo Shin, Myeon-Woo Chung   +7 more
doaj   +1 more source

Defining the right diluent for intravenous infusion of therapeutic antibodies

mAbs, 2020
Therapeutic monoclonal antibodies (mAbs) are commonly administered to patients through intravenous (IV) infusion, which involves diluting the medication into an infusion solution (e.g., saline and 5% dextrose).
Shen Luo, Keisha Melodi McSweeney, Tao Wang, Silvia M. Bacot, Gerald M. Feldman, Baolin Zhang   +5 more
doaj   +1 more source

Industry-scale application and evaluation of deep learning for drug target prediction [PDF]

, 2019
Artificial intelligence (AI) is undergoing a revolution thanks to the breakthroughs of machine learning algorithms in computer vision, speech recognition, natural language processing and generative modelling.
Ashby, Thomas J., Böhm, Stanislav, Ceulemans, Hugo, Chen, Hongming, Chupakhin, Vladimir, Cima, Vojtěch, Engkvist, Ola, Golib-Dzib, Jose-Felipe, Greene, Nigel, Hochreiter, Sepp, Jeliazkova, Nina, Klambauer, Günter, Martinovič, Jan, Mayr, Andreas, Sturm, Noe, Van, Thanh Le, Vander Aa, Tom, Vandriessche, Yves, Wegner, Joerg   +18 more
core   +2 more sources

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source