Results 81 to 90 of about 19,912,299 (390)

A headspace-gas chromatography method for isopropanol determination in warfarin sodium products as a measure of drug crystallinity

Acta Pharmaceutica, 2018
Coumadin® a nd s everal generic products of warfarin s odium (WS) contain the crystalline form (clathrate) in which WS and isopropanol (IPA) are associated in a 2:1 molar ratio. IPA is critical in maintaining the WS crystalline structure. Physicochemical
Rahman Ziyaur, Akhtar Sohail, Siddiqui Akhtar, Ciavarella Anthony B., Nguyenpho Agnes, Faustino Patrick J., Khan Mansoor A.   +6 more
doaj   +1 more source

Design, Preparation, and Evaluation of Enteric Coating Formulation of HPMC and Eudragit L100 on Carboxylated Agarose Hydrogel by Using Drug Tartrazine [PDF]

, 2022
Muhammad Junaid Khan, Wen-Can Huang, Muhammad Akhlaq, Sajid Raza, Alkassoumi Hassane Hamadou, Yuning Guo, Jianan Sun, Xiangzhao Mao   +7 more
openalex   +1 more source

A review of the evidence for the effectiveness of primary prevention interventions for Hepatitis C among injecting drug users [PDF]

, 2006
BACKGROUND Hepatitis C (HCV) prevalence is most common amongst injecting drug users where up to 98% of the population can be infected despite a low prevalence of HIV.
Tompkins, C.N.E., Wright, N.M.J.
core   +3 more sources

ADMET-score - a comprehensive scoring function for evaluation of chemical drug-likeness.

MedChemComm, 2019
Chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET), play key roles in drug discovery and development. A high-quality drug candidate should not only have sufficient efficacy against the therapeutic target, but also show ...
Longfei Guan, Hongbin Yang, Yingchun Cai, Lixia Sun, Peiwen Di, Weihua Li, Guixia Liu, Yun Tang   +7 more
semanticscholar   +1 more source

Drug Toxicity Evaluation Based on Organ-on-a-Chip Technology: A Review

Micromachines, 2020
Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in
Ye Cong, Xiahe Han, Youping Wang, Zongzheng Chen, Yao Lu, Tingjiao Liu, Zhengzhi Wu, Yu Jin, Yong Luo, Xiuli Zhang   +9 more
semanticscholar   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Cardiac Adverse Events in Patients Receiving Immune Checkpoint Inhibitors in the Adjuvant Setting: An FDA Pooled Analysis

Annals of Noninvasive Electrocardiology
Background Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. By releasing blocks (checkpoints) on the immune system, they elicit powerful antitumor effects.
Asma Dilawari, Mori J. Krantz, Ilynn Bulatao, Hee‐Koung Joeng, Marc Neilson, Suparna Wedam, Xin Gao, Mallorie H. Fiero, Abhilasha Nair, Marc Theoret, Laleh Amiri‐Kordestani   +10 more
doaj   +1 more source

Evaluation of 4-Aminoquinoline Hydrazone Analogues as Potential Leads for Drug-Resistant Malaria [PDF]

, 2023
Rachael N. Magwaza, Muna Abubaker, Buthaina Hussain, Michael Haley, Kevin N. Couper, Sally Freeman, Niroshini Nirmalan   +6 more
openalex   +1 more source

Factors associated with the performance and cost-effectiveness of using lymphatic filariasis transmission assessment surveys for monitoring soil-transmitted helminths: a case study in Kenya. [PDF]

, 2015
Transmission assessment surveys (TAS) for lymphatic filariasis have been proposed as a platform to assess the impact of mass drug administration (MDA) on soil-transmitted helminths (STHs).
Assefa, Aurenhammer, Bergquist, Birgit Nikolay, Brooker, Brooker, Charles S. Mwandawiro, Chu, de Silva, Edwards, Gunawardena, Hall, Hugh J. W. Sturrock, Jennifer L. Smith, Jimmy Kihara, Jovani, Levecke, Linard, Liya Assefa, McCarthy, Minetti, Mwandawiro, Mwandawiro, Nikolay, Njenga, Olives, Patil, Pullan, Sammy M. Njenga, Simon J. Brooker, Smith, Solomon, Sturrock, Sturrock, Sturrock   +34 more
core   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source