Results 111 to 120 of about 3,934,714 (308)
World Allergy Organization Journal, 2021 Background: Multiple drug hypersensitivity syndrome (MDHS) results in treatment delay or failure and often results in severe drug hypersensitivity reactions.
Da Woon Sim +3 more
doaj
Drug Induced Hypersensitivity and the HLA Complex
Pharmaceuticals, 2010 Drug-induced hypersensitivity reactions are of major concern and present a burden for national healthcare systems due to their often severe nature, high rate of hospital admissions and high mortality. They manifest with a wide range of symptoms and signs,
Munir Pirmohamed, Ana Alfirevic
doaj +1 more source
Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]
, 2011 Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen +3 more
core +1 more source
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]
, 2016 Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe +20 more
core +2 more sources
Stokes' Drift and Hypersensitive Response with Dichotomous Markov Noise [PDF]
Fluctuations and Noise Letters 5, L397-L415 (2005)., 2005 Stochastic Stokes' drift and hypersensitive transport driven by dichotomous noise are theoretically investigated. Explicit mathematical expressions for the asymptotic probability density and drift velocity are derived including the situation in which particles cross unstable fixed points. The results are confirmed by numerical simulations.
arxiv
Detecting drug-drug interactions using artificial neural networks and classic graph similarity measures [PDF]
, 2019 Drug-drug interactions are preventable causes of medical injuries and often result in doctor and emergency room visits. Computational techniques can be used to predict potential drug-drug interactions. We approach the drug-drug interaction prediction problem as a link prediction problem and present two novel methods for drug-drug interaction prediction
arxiv +1 more source
Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches
International Journal of Molecular Sciences, 2017 Drug hypersensitivity reactions (HSRs) are increasing in the 21st Century with the ever expanding availability of new therapeutic agents. Patients with cancer, chronic inflammatory diseases, cystic fibrosis, or diabetes can become allergic to their first
Leticia de las Vecillas Sánchez +3 more
semanticscholar +1 more source
Successful Desensitization of a Patient with Rituximab Hypersensitivity
Case Reports in Immunology, 2015 Rituximab is a monoclonal antibody which targets CD20 in B cells that is used for the treatment of CD20 positive oncologic and hematologic malignancies. Rituximab causes hypersensitivity reactions during infusions.
Pinar Ataca +4 more
doaj +1 more source
Noncovalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions [PDF]
, 2018 Drug-induced hypersensitivity reactions are instructive examples of immune reactions against low molecular weight compounds. Classically, such reactions have been explained by the hapten concept, according to which the small antigen covalently modifies ...
Gerber, Basil, Pichler, Werner
core
Semi-Supervised Hierarchical Drug Embedding in Hyperbolic Space [PDF]
arXiv, 2020 Learning accurate drug representation is essential for tasks such as computational drug repositioning and prediction of drug side-effects. A drug hierarchy is a valuable source that encodes human knowledge of drug relations in a tree-like structure where drugs that act on the same organs, treat the same disease, or bind to the same biological target ...
arxiv