Results 131 to 140 of about 3,996,783 (390)

Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans [PDF]

, 2014
Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra.
A Garcia-Espana, A Moszczynska, A Priyadarshi, Alexander Holmes, Anton Gartner, AT Allen, B Giros, C Boucheix, C Boucheix, C Boucheix, C Klein, C Missale, CD Dunn, CH Lai, D Vallone, DB Calne, DL Chase, E Rubinstein, E Rubinstein, EA Bolan, ER Sawin, ES Calipari, FJ Lee, FJ Lee, GC Cotzias, GR Uhl, H Maharaj, H Moribe, H Moribe, HP Rang, J Bove, J Sulston, JE Galvin, JG White, JM Beaulieu, JW Langston, K Jellinger, K Strange, K Tieu, KF Tipton, Kim A. Caldwell, L Carvelli, LD Jayanthi, M Santiago, MJ Ferris, MJ LaVoie, MJ Zigmond, ML Toth, MS Szczypka, MW Davis, MY Chang, N Chen, Neda Masoudi, O Thompson, P Seeman, P Seeman, P Sokoloff, Pablo Ibanez-Cruceyra, PW McDonald, QY Zhou, R Andrew, R Nass, R Nass, RM Kostrzewa, RR Gainetdinov, S Brenner, S Cao, S Charrin, S Fahn, S Fahn, S Thaminy, Sarah-Lena Offenburger, TN Chase, W Birkmayer, WA Cass, Y Glinka   +75 more
core   +4 more sources

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani, Hao Li, Panpan Guo, Qiulin Zhang, Mahmoud M. Abouelfetouh, Mingxing Ding, Yi Ding   +6 more
wiley   +1 more source

Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]

, 2018
BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core  

Classification of Drug Hypersensitivity into Allergic, p-i, and Pseudo-Allergic Forms

International Archives of Allergy and Immunology, 2016
Drug hypersensitivity reactions (DHR) are clinically and functionally heterogeneous. Different subclassifications based on timing of symptom appearance or type of immune mechanism have been proposed. Here, we show that the mode of action of drugs leading
W. Pichler, O. Hausmann
semanticscholar   +1 more source

Animal models of cisplatin‐induced neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
This article illustrates the modeling process of a cisplatin‐induced neuropathic pain model in rats or mice. Multiple modeling tests are required for rats or mice before, during, and after modeling. The appropriate injection method, dose, and modeling method are selected, and multiple assays are chosen for evaluation and comparison.
Ningxin Li, Mingzhu Li, Shengbo Jin, Jun Yu, Hongzhe Wei, Wenping Wang, Siyao Ma, Yuxin Jiang, Qian Liu, Huini Yao   +9 more
wiley   +1 more source

Hypersensitivity to chemotherapeutic drugs for the treatment of neoplasms. Literature review

Infusion & Chemotherapy
BACKGROUND. Like any other drug, chemotherapy drugs can cause hypersensitivity reactions and are the third leading cause of drug-induced anaphylaxis deaths in the United States.
S.V. Zaikov, M.A. Lykova, N.A. Hritsova, L.V. Veselovsky   +3 more
doaj   +1 more source

Model Systems for the Study of Drug Hypersensitivity [PDF]

, 1969
Donald R. Hoffman, Dan H. Campbell
openalex   +1 more source

Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America

Clinical and Translational Allergy, 2017
Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare severe cutaneous allergic reactions.
Marta E. Torres, A. Romano, G. Celik, P. Demoly, D. Khan, E. Macy, Miguel Park, K. Blumenthal, W. Aberer, M. Castells, A. Barbaud, C. Mayorga, P. Bonadonna   +12 more
semanticscholar   +1 more source

Randomized, Double‐Blind, Placebo‐Controlled, Multiple‐Dose Studies to Assess the Safety and Efficacy of Elezanumab when Added to Standard of Care in Relapsing and Progressive Forms of Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Elezanumab is a monoclonal antibody that binds repulsive guidance molecule a (RGMa), an inhibitor of central nervous system regeneration after inflammation or injury. The aim was to assess the safety and efficacy of elezanumab in relapsing and progressive forms of multiple sclerosis (MS).
Bruce A.C. Cree, Mark S. Freedman, Michael Gold, Kimberly Pfleeger, Brittany Schwefel, Annette Wundes, Adam Ziemann   +6 more
wiley   +1 more source

Cefoperazone induced hypersensitivity vasculitis

Indian Journal of Dermatology, 2009
Cefoperazone has been reported to cause vasculitic complications only once before. Here, we report yet another case of hypersensitivity vasculitis associated with cefoperazone.
Katiyar Subodh, Prakash Shivesh
doaj