Results 141 to 150 of about 3,996,783 (390)
Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy
Advanced NanoBiomed Research, EarlyView.Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali +7 more
wiley +1 more source
Deutsches Ärzteblatt International, 2018 BACKGROUND Adverse drug reactions (ADRs) can be divided into pharmacological ADRs (type A) and hypersensitivity reactions (type B). Type B reactions can be further subdivided into immediate (1 h, variable manifestation like exanthema, hepatitis ...
R. Böhm +3 more
semanticscholar +1 more source
A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature. [PDF]
, 2017 BACKGROUND Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint
Adderley +13 more
core +2 more sources
Advances on Albumin‐Based Carriers for Anticancer Drug Delivery
Advanced NanoBiomed Research, EarlyView.This study systematically classifies the drug delivery modes of albumin by examining the characteristics of its surface‐active groups and internal binding sites. It provides an in‐depth analysis of various drug delivery strategies and their corresponding targeting mechanisms.
Ruoli Zhou +4 more
wiley +1 more source
The Association of Increased Spontaneous Lymphocyte Transformation in Vitro with Clinical Manifestations of Drug Hypersensitivity [PDF]
, 1967 Fred A. Gill
openalex +1 more source
In Vitro Diagnosis of Immediate Drug Hypersensitivity Anno 2017: Potentials and Limitations
Drugs in R&D, 2017 BackgroundFor most physicians, quantification of drug-specific immunoglobulin E (drug-sIgE) antibodies constitutes the primary in vitro measure to document immediate drug hypersensitivity reactions (IDHR).
I. Decuyper +11 more
semanticscholar +1 more source
Immunological Mechanisms of Drug Hypersensitivity
Current Pharmaceutical Design, 2017 Drug hypersensitivity reactions (DHRs) are adverse drug reactions that may be divided into several categories; namely pharmacologic intolerance, idiosyncratic reactions, pseudo-allergic reactions and allergic reactions. Drug allergic reactions are those DHRs that are mediated by either antibodies or drug-specific T cells. They vary in terms of severity,
Adriana Ariza +4 more
openaire +3 more sources
The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Angewandte Chemie International Edition, EarlyView.Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl +6 more
wiley +1 more source
Carboplatin hypersensitivity in relapsed ovarian carcinoma: A therapeutic challenge
Indian Journal of Medical and Paediatric Oncology, 2014 Carboplatin and paclitaxel as doublet are the standard therapeutic option for advanced stage ovarian carcinoma in the first line as well as relapse. Carboplatin with its better toxicity profile has replaced cisplatin as the first line drug.
Avinash Pandey +6 more
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Despite availability of biologics and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) to treat rheumatoid arthritis (RA), many patients do not experience optimized disease control. Glucocorticoids are effective but have safety risks.
Frank Buttgereit +13 more
wiley +1 more source