Results 251 to 260 of about 1,960,750 (298)
General considerations on rapid desensitization for drug hypersensitivity – a consensus statement
Allergy: European Journal of Allergy and Clinical Immunology, 2010 Drug hypersensitivity reactions can occur with most drugs, are unpredictable, may affect any organ or system, and range widely in clinical severity from mild pruritus to anaphylaxis. In most cases, the suspected drug is avoided in the future.
Maria José Tôrres Jaen, Pascal Demoly
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Drug Hypersensitivity Reactions
Medical Clinics of North America, 2020Drug hypersensitivity reactions (DHRs) may be classified based on timing (immediate vs delayed), mechanisms, and pattern of clinical manifestations. Management may include selection of alternative, non-cross reactive agents, drug allergy testing, graded challenge and/or desensitization.
Mark S, Dykewicz, Jason K, Lam
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In Vitro Tests in Drug Hypersensitivity Diagnosis
Immunology and Allergy Clinics of North America, 2009 The diagnosis of a drug hypersensitivity reaction (DHR) is a challenging task because multiple and complex mechanisms are involved. Better understanding of immunologic pathomechanisms in DHRs and rapid progress in cellular-based in-vitro tests can help ...
Werner J Pichler
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Tools to investigate and avoid drug-hypersensitivity in drug development
Expert Opinion on Drug Discovery, 2018 Drug hypersensitivity reactions (DHRs) are common adverse effects of pharmaceuticals that clinically resemble allergies, and which are becoming an important burden to healthcare systems.
Marc Pallardy +2 more
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Hypersensitivity to Antiepileptic Drugs
Immunology and Allergy Clinics of North America, 2014Adverse reactions to antiepileptic drugs (AEDs) may lead to treatment failure, morbidity, and mortality. Drug hypersensitivity reactions (DHRs) are potentially fatal. AED DHRs present with a variety of clinical manifestations. The pathogenesis of AED DHRs has not been fully elucidated.
Young-Min, Ye +2 more
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Immunology and Allergy Clinics of North America, 2014
Before the arrival of modern pharmacotherapy, drug hypersensitivity reactions were virtually unknown. Toxicity from the many plant-, animal- and inorganic material-derived remedies must have been much more common. One famous example is the intoxications from mercury, which has been used in many ailments, but particularly for the treatment of syphilis ...
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Before the arrival of modern pharmacotherapy, drug hypersensitivity reactions were virtually unknown. Toxicity from the many plant-, animal- and inorganic material-derived remedies must have been much more common. One famous example is the intoxications from mercury, which has been used in many ailments, but particularly for the treatment of syphilis ...
openaire +4 more sources
Hypersensitivity drug reactions
Current Opinion in Allergy & Clinical Immunology, 2014In this new issue of Current Opinion in Allergy and Clinical Immunology, five major areas of research in the field of hypersensitivity reactions to drugs in the past year are reviewed. The manuscript of Blanca-Lopez et al.[1] is devoted to hypersensitivity reactions to NSAIDs.
Bernard Y, Thong, Miguel, Blanca
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Medical Clinics of North America, 2006
Allergic drug reactions compose a small percentage of ADRs, yet they are commonly encountered in clinical practice, and physicians are taught routinely to question patients about these reactions during history taking. Among antibiotics, the immunochemistry of penicillins has been elucidated,leading to the development of validated skin test reagents to ...
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Allergic drug reactions compose a small percentage of ADRs, yet they are commonly encountered in clinical practice, and physicians are taught routinely to question patients about these reactions during history taking. Among antibiotics, the immunochemistry of penicillins has been elucidated,leading to the development of validated skin test reagents to ...
openaire +2 more sources
Immediate Drug Hypersensitivity
Current Allergy and Asthma Reports, 2016Drug allergy affects a large percentage of the general population. A listed drug allergy can also have broad implications for many aspects of patient care. Here, we will review recent advances in the arena of drug allergies with a focus on antibiotics, monoclonals, NSAIDs, and chemotherapeutics.
Paige G, Wickner, David, Hong
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Pediatric Drug Hypersensitivity
Current Allergy and Asthma Reports, 2019Pediatric drug hypersensitivity is a rapidly evolving field. The purpose of this paper is to review the current state of pediatric drug hypersensitivity and highlight new developments in diagnosis and management.This paper will discuss the safety and use of risk stratification to proceed directly to oral challenge without prior skin testing for β ...
Christine R F, Rukasin +2 more
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