Results 101 to 110 of about 146,608 (306)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
EVA implants for controlled drug delivery to the inner ear
International Journal of Pharmaceutics: XThis study evaluated the potential of poly(ethylene vinyl acetate) (EVA) copolymers as matrix formers in miniaturised implants, allowing to achieve controlled drug delivery into the inner ear.
Y. Bedulho das Lages +9 more
doaj +1 more source
Development of Implants for Prolonged Drug delivery
British Journal of Pharmacy, 2019 Despite being a popular and convenient route of drug delivery, the oral route has a number of disadvantages. Polymeric sub-dermal implants offer an alternative delivery route that may circumvent many of these challenges.
Sarah Anne Stewart +2 more
doaj +1 more source
Development and Micro Manufacturing of Coronary Stents in Hungary [PDF]
, 2006 Revascularisation by endovascular implant (stent) has great importance in the treatment of coronary artery diseases. Stents are high-technology implants that are the creation of the knowledge of health sciences, physics, chemistry, material science and
Dobránszky, János +3 more
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Development of coronary stents using advanced results of materials science and technology [PDF]
, 2004 Stents are high tech endovascular implants. K&M Inc. is the single Eastern European stent producer company. The market needs more biocompatible devices as the trend of the stent development all the producers have to react.
Dobránszky, János +3 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source