Results 131 to 140 of about 1,989,460 (302)

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Implantable Drug Delivery Systems: Practical Considerations

Journal of Pain and Symptom Management, 1990
Spinal opioids have dramatically changed the way acute, obstetrical and pain of malignant origin is managed. The development of various implantable narcotic delivery systems has complemented and facilitated the growth of this treatment modality. By interfacing appropriate patient selection with the unique advantages and disadvantages of each of the six
openaire   +2 more sources

National drug-related public expenditure online resource.

, 2021
This is the first set of national profiles that the EMCDDA has produced on drug-related public expenditure. The profiles are based on the sections on public expenditure provided by the 27 EU Member States, Croatia, Turkey and Norway in the national ...

core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Multi-scale in silico and ex silico mechanics of 3D printed cochlear implants for local drug delivery

Frontiers in Bioengineering and Biotechnology
The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects.
A. Isaakidou, M. Ganjian, R. van Hoften, M. C. Saldivar, M. A. Leeflang, A. Groetsch, A. Groetsch, M. Wątroba, J. Schwiedrzik, M. J. Mirzaali, I. Apachitei, L. E. Fratila-Apachitei, A. A. Zadpoor   +12 more
doaj   +1 more source

PLGA implants: How Poloxamer/PEO addition slows down or accelerates polymer degradation and drug release

, 2017
International audienceThe aim of this study was to evaluate the impact of the addition of small amounts of hydrophilic polymers (Poloxamer 188 and PEO 200 kDa) to PLGA-based implants loaded with prilocaine.
Siepmann, Juergen, M.C. Hamoudi-Ben Yelles, J. Siepmann, V. Tran Tan, Hamoudi-Ben Yelles, M.C., F. Danede, J.F. Willart, Danede, Florence, Willart, Jean-François, Tran Tan, V.   +9 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Short implants compared to implants in vertically augmented bone: a systematic review

, 2015
To assess relevant data comparing short implants or implants associated with vertical ridge augmentation derived from RCT's and CCT ...
Picard, N, Nisand, D, D. Nisand, N. Picard, I. Rocchietta, Rocchietta, Isabella,   +5 more
core   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Characterization of PLGA versus PEG-PLGA intracochlear drug delivery implants: Degradation kinetics, morphological changes, and pH alterations

Drug delivery to the inner ear presents a unique challenge due to the complex inner ear anatomy and its tight physiological barriers. This study investigates the degradation behavior of intracochlear drug delivery implants (IDDI) composed of ...
Mäder, Karsten, Liebau, Arne, Knolle, Wolfgang, Binder, Wolfgang H., Scheffler, Jonas, Schmelzer, Christian E.H., Lehner, Eric, Menzel, Matthias, Plontke, Stefan K.   +8 more
core   +1 more source