Results 141 to 150 of about 151,635 (354)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Multi-scale in silico and ex silico mechanics of 3D printed cochlear implants for local drug delivery

Frontiers in Bioengineering and Biotechnology
The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects.
A. Isaakidou, M. Ganjian, R. van Hoften, M. C. Saldivar, M. A. Leeflang, A. Groetsch, A. Groetsch, M. Wątroba, J. Schwiedrzik, M. J. Mirzaali, I. Apachitei, L. E. Fratila-Apachitei, A. A. Zadpoor   +12 more
doaj   +1 more source

Spartan Daily, November 13, 1991 [PDF]

, 1991
Volume 97, Issue 52https://scholarworks.sjsu.edu/spartandaily/8189/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +2 more sources

Risk Factors Associated with Postoperative Cerebrospinal Fluid Leaks After Intrathecal Drug Delivery System and an External Pump Implantation in Cancer Patients: A Retrospective Study [PDF]

Yuan Li, Shuwu Zhao, Keith Candiotti, Chen Su   +3 more
openalex   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

A tissue-like polymeric drug delivery implant for local cancer therapy

, 2016
Aikaterini Mantzavinou, Cima Michael
openalex   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

TiO2 nanotube platforms for smart drug delivery: a review

International Journal of Nanomedicine, 2016
Qun Wang,1,2,* Jian-Ying Huang,1,* Hua-Qiong Li,3 Zhong Chen,4 Allan Zi-Jian Zhao,3 Yi Wang,3 Ke-Qin Zhang,1 Hong-Tao Sun,2 Salem S Al-Deyab,5 Yue-Kun Lai1 1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering ...
Wang Q, Huang JY, Li HQ, Chen Z, Zhao AZJ, Wang Y, Zhang KQ, Sun HT, Al-Deyab SS, Lai YK   +9 more
doaj