Results 11 to 20 of about 151,635 (354)

A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation [PDF]

, 2020
Using a novel molecular design approach, we have prepared a thermo-responsive supramolecular polyurethane as a matrix material for use in drug eluting implants.
Clark, E. A., Evangelista Barreiros, M. I., Greco, F., Hart, L. R., Hayes, W., Khaled, S., Natfji, A. A., Roberts, C. J., Salimi, S., Wildman, R., Wu, Y.   +10 more
core   +2 more sources

Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. [PDF]

, 2007
BackgroundThe SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo.
A Adachi, A Valentin, April N. Kinkade, Barbara Sloan, BD Jamieson, BD Jamieson, BK Berges, BS Robinson, CA Stoddart, CA Stoddart, CA Stoddart, Cheryl A. Bales, Cheryl A. Stoddart, E De Clercq, ED Miller, EJ Freireich, ES Withers-Ward, G Kovalev, George Chkhenkeli, GM Aldrovandi, GM Aldrovandi, GM Aldrovandi, H Kaneshima, H Kaneshima, J McCune, J Mordenti, Jennifer C. Bare, JF Krowka, JM McCune, JM McCune, JM McCune, JM McCune, JM Strizki, José M. Rivera, JY Feng, L Rabin, L Su, L Su, L Zhang, Linqi Zhang, LT Rimsky, M Markowitz, Mary E. Moreno, ME Keir, MG Manz, ML Bonyhadi, ML Greenberg, Paul L. Black, PS Koka, R Datema, R Namikawa, R Namikawa, RC Bast, RD Berkowitz, RD Berkowitz, RD Berkowitz, RD Berkowitz, RG Amado, Rollie E. Ronquillo, S Baenziger, S Gartner, S Gorantla, SD Young, SG Kitchen, SG Kitchen, SK Stanley, Sofiya A. Galkina, Z Sun   +67 more
core   +7 more sources

Fabrication and Characterisation of 3D-Printed Triamcinolone Acetonide-Loaded Polycaprolactone-Based Ocular Implants

Pharmaceutics, 2023
Triamcinolone acetonide (TA) is a corticosteroid that has been used to treat posterior segment eye diseases. TA is injected intravitreally in the management of neovascular disorders; however, frequent intravitreal injections result in many potential side
Febri Annuryanti, Juan Domínguez-Robles, Qonita Kurnia Anjani, Muhammad Faris Adrianto, Eneko Larrañeta, Raghu Raj Singh Thakur   +5 more
doaj   +1 more source

Pharmacokinetic Study of Islatravir and Etonogestrel Implants in Macaques

Pharmaceutics, 2023
The prevention of HIV and unintended pregnancies is a public health priority. Multi-purpose prevention technologies capable of long-acting HIV and pregnancy prevention are desirable for women. Here, we utilized a preclinical macaque model to evaluate the
Michele B. Daly, Andres Wong-Sam, Linying Li, Archana Krovi, Gregory J. Gatto, Chasity Norton, Ellen H. Luecke, Victoria Mrotz, Catalina Forero, Mackenzie L. Cottrell, Amanda P. Schauer, Joy Gary, Josilene Nascimento-Seixas, James Mitchell, Ariane van der Straten, Walid Heneine, J. Gerardo Garcίa-Lerma, Charles W. Dobard, Leah M. Johnson   +18 more
doaj   +1 more source

3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs

Drug Delivery, 2022
Implantable drug delivery systems offer an alternative for the treatments of long-term conditions (i.e. schizophrenia, HIV, or Parkinson’s disease among many others).
Camila J. Picco, Juan Domínguez-Robles, Emilia Utomo, Alejandro J. Paredes, Fabiana Volpe-Zanutto, Dessislava Malinova, Ryan F. Donnelly, Eneko Larrañeta   +7 more
doaj   +1 more source

Avaliação da mucosa sinusal do coelho à presença de implante biodegradável Assessing the maxillary sinus mucosa of rabbits in the presence of biodegradable implants

Brazilian Journal of Otorhinolaryngology, 2012
Pensando em melhorar a qualidade de vida dos pacientes com doenças do humor vítreo, os oftalmologistas começaram a utilizar recentemente implantes biodegradáveis com corticoide.
André Coura Perez, Armando da Silva Cunha Junior, Sílvia Ligório Fialho, Lívia Mara Silva, João Vicente Dorgam, Adriana de Andrade Batista Murashima, Alfredo Ribeiro Silva, Maria Rossato, Wilma Terezinha Anselmo-Lima   +8 more
doaj   +1 more source

How bulk fluid renewal can affect in vitro drug release from PLGA implants: Importance of the experimental set-up

International Journal of Pharmaceutics: X, 2022
The aim of this study was to better understand the potential impact of partial vs. complete renewal of the bulk fluid during drug release measurements from poly (lactic-co-glycolic acid) (PLGA)-based implants.
C. Bassand, L. Benabed, J. Freitag, J. Verin, F. Siepmann, J. Siepmann   +5 more
doaj   +1 more source

Enzymatic activity toward poly(L-lactic acid) implants [PDF]

, 1990
Tissue reactions toward biodegradable poly(L-lactic acid) implants were monitored by studying the activity pattern of seven enzymes as a function of time: alkaline phosphatase, acid phosphatase, -naphthyl acetyl esterase, -glucuronidase, ATP-ase, NADH ...
Feijen, J., Hardonk, M.J., Molenaar, I., Nieuwenhuis, P., Schakenraad, J.M.   +4 more
core   +4 more sources

Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants

Drug Delivery, 2020
Etoposide (VP16) is the traditional antitumor agent which has been widely used in a variety of cancers. However, intravenous administration of VP16 was limited in clinical application because of its low aqueous solubility, poor bioavailability and dose ...
Chunsheng Wu, Xiangting Yi, Renzhi Xu, Maokuan Zhang, Yan Xu, Yan Ma, Li Gao, Zhengbao Zha   +7 more
doaj   +1 more source

Comparative Analysis of Morphological and Release Profiles in Ocular Implants of Acetazolamide Prepared by Electrospinning

Pharmaceutics, 2021
The visual impairment that often leads to blindness causes a higher morbidity rate. The goal of this work is to create a novel biodegradable polymeric implant obtained from coaxial fibers containing the dispersed drug—acetazolamide—in order to achieve ...
Mariana Morais, Patrícia Coimbra, Maria Eugénia Pina   +2 more
doaj   +1 more source