Results 91 to 100 of about 4,952,093 (307)
Beilstein Journal of Organic Chemistry, 2018 In order to prepare asymmetrically (R)-(+)-1-(5-bromopentyl)-1-methyl-7-methoxy-2-tetralone (3a), a key intermediate of dezocine, 17 cinchona alkaloid-derived catalysts were prepared and screened for the enantioselective alkylation of 1-methyl-7-methoxy ...
Ruipeng Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Regulations Governing Drug Trials in Turkey
, 2003 The ethical issues involved in drug trials using human subjects have become a challenge to the investigators involved. The needs of the drug industry and the increase in the number of such trials have added to these problems.
Aydin, Erdem
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Midlands awareness group concerned by impact of virus on the drug industry.
, 2020 Lockdown restrictions are impacting the ability of drug dealers to reach their market.
core
Industry super and the Australian economy [PDF]
, 2016 This report highlights Australia’s not-for-profit industry super funds are effectively leveraging the scale and long-term investment horizon to invest in real economy assets which have been the foundation of superior member returns. This study attempts
Industry Super Australia
core +1 more source
A (des)informação sobre medicamentos: o duplo padrão de conduta das empresas farmacêuticas
Cadernos de Saúde PúblicaDiferentes fatores foram identificados como exercendo influência sobre o comportamento dos prescritores de medicamentos. Estudos realizados enfatizam o lugar proeminente ocupado pelas fontes de informação disponíveis para os médicos, muitos deles ...
José Augusto C. Barros
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Perspectives on drugs: Drug consumption rooms: an overview of provision and evidence. [PDF]
, 2016 Supervised drug consumption facilities, where illicit drugs can be used under the supervision of trained staff, have been operating in Europe for the last three decades.
core
A concise and practical stereoselective synthesis of ipragliflozin L-proline
Beilstein Journal of Organic Chemistry, 2017 A concise and practical stereoselective synthesis of ipragliflozin L-proline was presented starting from 2-[(5-iodo-2-fluorophenyl)methyl]-1-benzothiophene and 2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide without catalyst via iodine–lithium–zinc ...
Shuai Ma +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source