Results 81 to 90 of about 948,070 (312)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
A novel and practical asymmetric synthesis of eptazocine hydrobromide
Beilstein Journal of Organic Chemistry, 2018 In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide.
Ruipeng Li +5 more
doaj +1 more source
Can’t Buy Me Rights! The Contractual Structure of Asymmetrical Inter-firm Collaborations [PDF]
, 2006 The efficient allocation of control rights in inter-firm collaborations is a widely emphasized issue. In this paper, I empirically identify control rights and the allocation of these rights using a unique survey data set on collaborations between ...
Häussler, Carolin
core +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Cadernos de Saúde PúblicaEm caráter exploratório, o objetivo deste artigo é investigar se há indícios de especialização regressiva no padrão de comércio exterior da indústria farmacêutica brasileira, a partir da liberalização comercial dos anos 1990.
Fábio Batista Mota +2 more
doaj
Cadernos de Saúde PúblicaResumo: A Parceria para o Desenvolvimento Produtivo (PDP) é uma das medidas usada pelo Estado brasileiro para incentivar a política de inovação, ampliar o acesso da população a medicamentos estratégicos e reduzir a dependência tecnológica do país, por ...
Daniela Rangel Affonso Fernandes +2 more
doaj +1 more source
AMB Express, 2019 Ascomycin, a key intermediate for chemical synthesis of immunosuppressive drug pimecrolimus, is produced by Streptomyces hygroscopicus var. ascomyceticus. In order to improve the strain production, the original S.
Zhituo Yu +5 more
doaj +1 more source
Alcohol and other drugs in the Australian construction industry: a pathway for safety focused cultural change [PDF]
, 2013 Background: Anecdotal evidence from the infrastructure and building sectors highlights issues of alcohol and other drugs (AODs) and its association with safety risk on construction sites.
Biggs, Herbert, Williamson, Amy
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
The Determinants of Pharmaceutical R&D Expenditures: Evidence from Japan [PDF]
During the past 20 years, the world pharmaceutical industry has experienced a dramatic increase in R&D intensity. We apply and extend a model developed by Grabowski and Vernon (2000) with a pooled data sample of the 15 publicly listed Japanese drug firms
Mahlich, Jörg C. +1 more
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