Results 101 to 110 of about 5,201,027 (314)

Enhancement of ascomycin production via a combination of atmospheric and room temperature plasma mutagenesis in Streptomyces hygroscopicus and medium optimization

AMB Express, 2019
Ascomycin, a key intermediate for chemical synthesis of immunosuppressive drug pimecrolimus, is produced by Streptomyces hygroscopicus var. ascomyceticus. In order to improve the strain production, the original S.
Zhituo Yu, Xiaofang Shen, Yuanjie Wu, Songbai Yang, Dianwen Ju, Shaoxin Chen   +5 more
doaj   +1 more source

Drug Overdose Mortality by Usual Occupation and Industry: 46 U.S. States and New York City, 2020 [PDF]

Objective\u2014This report describes deaths from drug overdoses in 2020 in U.S. residents in 46 states and New York City by usual occupation and industry.Methods\u2014Frequencies, death rates, and proportionate mortality ratios (PMRs) are presented using

core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

A (des)informação sobre medicamentos: o duplo padrão de conduta das empresas farmacêuticas

Cadernos de Saúde Pública
Diferentes fatores foram identificados como exercendo influência sobre o comportamento dos prescritores de medicamentos. Estudos realizados enfatizam o lugar proeminente ocupado pelas fontes de informação disponíveis para os médicos, muitos deles ...
José Augusto C. Barros
doaj  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Enantioselective phase-transfer catalyzed alkylation of 1-methyl-7-methoxy-2-tetralone: an effective route to dezocine

Beilstein Journal of Organic Chemistry, 2018
In order to prepare asymmetrically (R)-(+)-1-(5-bromopentyl)-1-methyl-7-methoxy-2-tetralone (3a), a key intermediate of dezocine, 17 cinchona alkaloid-derived catalysts were prepared and screened for the enantioselective alkylation of 1-methyl-7-methoxy ...
Ruipeng Li, Zhenren Liu, Liang Chen, Jing Pan, Weicheng Zhou   +4 more
doaj   +1 more source

National Campaign Against Drug Abuse Social Issues Survey, 1988

, 2018
Since 1985, as part of the National Campaign Against Drug Abuse, substantial survey research has been undertaken to assess the extent of drug problems, the effectiveness of interventions, and the impact of aspects of the campaign.
Drugs of Dependence Branch, National Drug Abuse Information Centre
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Indústria do conhecimento: uma poderosa engrenagem

Revista de Saúde Pública
O artigo aborda a articulação da indústria farmacêutica à indústria do conhecimento, por meio de poderosas estratégias de marketing. Com o objetivo de legitimar cientificamente seus produtos, a indústria interfere na produção de conhecimento médico ...
Vera Regina da Silva Miguelote, Kenneth Rochel de Camargo Jr   +1 more
doaj  

A concise and practical stereoselective synthesis of ipragliflozin L-proline

Beilstein Journal of Organic Chemistry, 2017
A concise and practical stereoselective synthesis of ipragliflozin L-proline was presented starting from 2-[(5-iodo-2-fluorophenyl)methyl]-1-benzothiophene and 2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide without catalyst via iodine–lithium–zinc ...
Shuai Ma, Zhenren Liu, Jing Pan, Shunli Zhang, Weicheng Zhou   +4 more
doaj   +1 more source