Results 131 to 140 of about 938,469 (359)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer

Nature Communications
Although ubiquitin-conjugating enzymes are critical regulators of cellular function and fate, their roles in tumorigenesis remain incompletely defined.
Shiqun Wang, Wenyan Yang, Ti Peng, Chunxiao Zhu, Jinyun Dong, Yichao Wang, Hu Yuan, Qingyan Sun, Xin Luan, Xiaoqing Guan, Weidong Zhang, Jiang-Jiang Qin   +11 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Drug Innovations and Welfare Measures Computed from Market Demand: The Case of Anti-Cholesterol Drugs [PDF]

The pharmaceutical industry is characterized as having substantial investment in R&D and a large number of new product introductions, which poses special problems for price measurement caused by the quality of drug products changing over time. This paper
Abe Dunn
core  

A Profile of the Philippine Pharmaceutical Sector [PDF]

, 2011
The Philippines is one of the biggest pharmaceutical markets in the ASEAN region, next only to Indonesia and Thailand. It is a lifeline to thousands of Filipino workers and a significant contributor in terms of value of output.
Asis, Ronina D., Datu, Maria Blesila G., Lavado, Rouselle F., Reyes, Celia M., Tabuga, Aubrey D.   +4 more
core  

Datura stramonium L.—The Toxicological Aspects of an Alternative Drug of Abuse

Proceedings
Datura stramonium, commonly known as jimsonweed or Devil’s trumpet, belongs to the Solanaceae family and has a long history of medicinal and toxicological importance [...]
Dalia-Maria Horşia (Pătrașcu), Noni Ștefan Marcu, Alex-Robert Jîjie, Elena-Alina Moacă, Oana Andrada Iftode, Cristina Adriana Dehelean   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Saúde e inovação: uma abordagem sistêmica das indústrias da saúde

Cadernos de Saúde Pública
Partindo do reconhecimento da importância da geração e da difusão de inovações para o desenvolvimento sócio-econômico nos países capitalistas e do caráter sistêmico, institucional e histórico desse processo, o trabalho procura evidenciar a necessidade de
Carlos Augusto Grabois Gadelha, Cristiane Quental, Beatriz de Castro Fialho   +2 more
doaj  

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source