Results 161 to 170 of about 7,440,138 (398)
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Drug-induced torsade de pointes: the perspectives of industry [PDF]
, 2001 Leif Carlsson
openalex +3 more sources
Stochastic Ordering under Conditional Modelling of Extreme Values: Drug-Induced Liver Injury [PDF]
arXiv, 2012 Drug-induced liver injury (DILI) is a major public health issue and of serious concern for the pharmaceutical industry. Early detection of signs of a drug's potential for DILI is vital for pharmaceutical companies' evaluation of new drugs. A combination of extreme values of liver specific variables indicate potential DILI (Hy's Law).
arxiv
The Sex Industry, Alcohol and Illicit Drugs: implications for the spread of HIV infection [PDF]
, 1989 Moira Plant +3 more
openalex +1 more source
A Gateway to Future Problems: Concerns about the State by-State Legalization of Medical Marijuana [PDF]
, 2015 [Excerpt] “Before 2009, every American presidential administration had been uniform in its policy of consistently enforcing the nation’s drug laws.
Lewis, Paul
core +1 more source
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
A novel and practical asymmetric synthesis of dapoxetine hydrochloride
Beilstein Journal of Organic Chemistry, 2015 A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.
Yijun Zhu +4 more
doaj +1 more source
Market Structure and Drug Innovation [PDF]
An explosion of knowledge and a growing array of tools and technologies have transformed modern drug R&D, while its cost has risen by a sizable amount.
Pammolli, Fabio, Riccaboni, Massimo
core +1 more source
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Drug Repurposing for Parkinson's Disease Using Random Walk With Restart Algorithm and the Parkinson's Disease Ontology Database [PDF]
arXivParkinson's disease is a progressive and slowly developing neurodegenerative disease, characterized by dopaminergic neuron loss in the substantia nigra region of the brain. Despite extensive research by scientists, there is not yet a cure to this problem and the available therapies mainly help to reduce some of the Parkinson's symptoms.
arxiv