Results 161 to 170 of about 2,100,146 (305)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

medicX-KG: a knowledge graph for pharmacists' drug information needs. [PDF]

J Biomed Semantics
Farrugia L, Azzopardi LM, Debattista J, Abela C.   +3 more
europepmc   +1 more source

How to meet patients' individual needs for drug information - a scoping review

, 2018
Marcel KP Kusch,1,2 Walter E Haefeli,1,2 Hanna M Seidling1,2 1Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, 69120 Heidelberg, Baden-Wurttemberg, Germany; 2Cooperation Unit Clinical Pharmacy, University of ...
Seidling HM, Haefeli WE, Kusch MKP
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Improving Online Drug Information: Insights from Quality Evaluation and Pharmaceutical System Design. [PDF]

Healthc Inform Res
Permatasari D, Syofyan, Yulianto AA, Qholbya W, Ridwan AA, Srangenge Y.   +5 more
europepmc   +1 more source

Health Literacy Level and Comprehension of Prescription and Nonprescription Drug Information. [PDF]

Int J Environ Res Public Health, 2022
Kim M, Suh D, Barone JA, Jung SY, Wu W, Suh DC.   +5 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Artificial Intelligence as a Drug Information Resource: Limitations and Strategies to Optimize in Pharmacy Practice. [PDF]

Hosp Pharm
Soujah C, Bejjani C, Adra N, Blackburn L.   +3 more
europepmc   +1 more source

Assessment of the scope, completeness, and consistency of various drug information resources related to COVID-19 medications in pregnancy and lactation. [PDF]

BMC Pregnancy Childbirth, 2023
Shareef J, Sridhar SB, Bhupathyraaj M, Shariff A, Thomas S, Salim Karattuthodi M.   +5 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source