Results 191 to 200 of about 1,978,039 (213)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies

Ca-A Cancer Journal for Clinicians, 2022
Shanu Modi, Cortes J, Roberto Carmagnani Pestana   +2 more
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Targeted drug delivery strategies for precision medicines

Nature Reviews Materials, 2021
Mandana Manzari, Maurizio Scaltriti, Daniel A Heller   +2 more
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Drug delivery to the central nervous system

Nature Reviews Materials, 2021
Elizabeth Nance, Suzie Pun, Drew Sellers   +2 more
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Kinase drug discovery 20 years after imatinib: progress and future directions

Nature Reviews Drug Discovery, 2021
Philip Cohen, Darren Cross, Pasi Janne   +2 more
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Food and Drug Administration, Partner in Drug Development

Ca-A Cancer Journal for Clinicians, 2006
J W Yates
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Efforts to control prescription drug abuse: Why clinicians should be concerned and take action as essential advocates for rational policy

Ca-A Cancer Journal for Clinicians, 2014
Aaron Gilson
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Determination of the Anticipated Therapeutic Effect of an Anticancer Drug in an Individual Patient

Ca-A Cancer Journal for Clinicians, 1964
R N Grant
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