Results 251 to 260 of about 11,447,845 (407)

MDG-DDI: multi-feature drug graph for drug-drug interaction prediction. [PDF]

BMC Bioinformatics
Li W, Zhou Y, Ma W, Liang W, Tang X.
europepmc   +1 more source

Drug–drug interaction between clobazam and cannabidiol in children with refractory epilepsy

Epilepsia, 2015
Alexandra L. Geffrey, Sarah F. Pollack, Patricia L. Bruno, E. Thiele   +3 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

DDI-CYP: Metabolism ensemble models for drug-drug interaction predictions. [PDF]

Drug Metab Dispos
Wong JT, Harris JS, Lane TR, Urbina F, Ekins S.   +4 more
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Advancing Drug-Drug Interaction Prediction with Biomimetic Improvements: Leveraging the Latest Artificial Intelligence Techniques to Guide Researchers in the Field. [PDF]

Biomimetics (Basel)
Marqas RB, Simó Z, Mousa A, Özyurt F, Iantovics LB.   +4 more
europepmc   +1 more source

In vitro evaluation of selected Indian spices for α-amylase and α-glucosidase inhibitory activities and their spice-drug interactions

, 2019
Nupur Mehrotra, Kaustubh Jadhav, Swati Rawalgaonkar, Sara Anees Khan, B. R. PAREKH   +4 more
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Graph neural network-based drug-drug interaction prediction. [PDF]

Sci Rep
Abbas K, Hao C, Yong X, Hasan MK, Islam S, Rahman AHA.   +5 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source