Results 151 to 160 of about 1,909,397 (348)
THE ASSESSMENT OF POTENTIAL DRUG INTERACTIONS WITH A NEW TRICYCLIC ANTIDEPRESSANT DRUG [PDF]
, 1974 Robin Briant, C. F. George
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Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
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Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
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IMPORTANT HERB-DRUG INTERACTIONS
Zdravniški Vestnik, 2004 Background. Herbal medicines have been popular for self-medication for a long time. Patients consider them to be safe because of their natural origin.
Javor Kac, Aleš Mlinarič
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Diflunisal: a review of pharmacokinetic and pharmacodynamic properties, drug interactions, and special tolerability studies in humans. [PDF]
, 1977 KF Tempero, VJ Cirillo, S L Steelman
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ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
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Importancia clínica de las interacciones medicamentosas
Revista Cubana de Higiene y EpidemiologíaSe realizó un estudio observacional descriptivo en 200 historias clínicas de pacientes ingresados en el Servicio de Medicina del Hospital Clinicoquirúrgico de "10 de Octubre", con el objetivo de evaluar posibles interacciones medicamentosas.
Caridad Peña Fleites +3 more
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Fluorescence studies of drug and cation interactions with microsomal membranes [PDF]
, 1973 Hilary C. Hawkins, Robert B. Freedman
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
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