Results 151 to 160 of about 1,999,544 (345)

Potential drug–drug interactions when managing status epilepticus patients in intensive care: A cohort study [PDF]

, 2021
Clémentine Le Roux, Alexandre Destère, Sarah Hervy, Célia Lloret‐Linares, Jean Reignier, Pascal Caillet, Pascale Jolliet, Bruno Mégarbane, D. Boels   +8 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

IMPORTANT HERB-DRUG INTERACTIONS

Zdravniški Vestnik, 2004
Background. Herbal medicines have been popular for self-medication for a long time. Patients consider them to be safe because of their natural origin.
Javor Kac, Aleš Mlinarič
doaj  

Cardiac Drug and Psychotropic Drug Interactions

, 2001
James J. Strain, G Caliendo, Jeffrey D. Alexis, Anwarul Karim, Mark Loigman, R S LoweIII   +5 more
openalex   +1 more source

Translational drug–interaction corpus

, 2022
Shijun Zhang, Heng‐Yi Wu, Lei Wang, Gongbo Zhang, Luís M. Rocha, Hagit Shatkay, Lang Li   +6 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Drug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats

Drug Design, Development and Therapy, 2019
Qiong Wang,1 Haiyun Wang,1 Youyan Zhong,1 Qiang Zhang2 1Department of Pharmacy, Wenzhou People’s Hospital, Wenzhou, Zhejiang 325000, People’s Republic of China; 2Department of Clinical Laboratory, The People’s Hospital of Lishui, Lishui,
Wang Q, Wang H, Zhong Y, Zhang Q
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Importancia clínica de las interacciones medicamentosas

Revista Cubana de Higiene y Epidemiología
Se realizó un estudio observacional descriptivo en 200 historias clínicas de pacientes ingresados en el Servicio de Medicina del Hospital Clinicoquirúrgico de "10 de Octubre", con el objetivo de evaluar posibles interacciones medicamentosas.
Caridad Peña Fleites, Olga María Menéndez Sánchez, Manuel Rivero Moreno, Nancy Yodú Ferral   +3 more
doaj  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source