Results 51 to 60 of about 1,999,544 (345)

Controlled release from zein matrices: Interplay of drug hydrophobicity and pH [PDF]

, 2015
Purpose: In earlier studies, the corn protein zein is found to be suitable as a sustained release agent, yet the range of drugs for which zein has been studied remains small.
A Katchalsky, AL Sarode, D Xiao, DMR Georget, Erik van der Linden, FA Momany, GW Selling, H Chiue, H Kortejärvi, Jacob Bouman, JW Lawton, M Fujiwara, M Peleg, N Minagawa, NA Peppas, P Argos, P Hurtado-López, Paul Venema, Peter Belton, PL Ritger, PS Belton, Q Jiang, R Paliwal, R Shukla, RA Granberg, Renko de Vries, S Grund, S Podaralla, S Thakral, Sheng Qi, W Huang, X Liu, YH Yong, YK Oh, YK Oh   +34 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Drug-drug interactions in repeat prescriptions at village dispensaries (bereg) in Malta [PDF]

, 2013
Inappropriate treatments and drug-drug interactions (DDIs) are known to occur in settings where repeat prescriptions are issued. In view of this, a study was carried out to document any such problematic drug prescribing and propose changes that would
Bugeja, Anton
core  

CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids [PDF]

, 2017
Purpose When codeine and tramadol are used for pain management, it is imperative that nurses are able to assess for potential drug-gene and drug-drug-gene interactions that could adversely impact drug metabolism and ultimately pain relief.
Broome, Marion E., Burke Draucker, Claire, Carpenter, Janet S., Holmes, Ann M., Knisely, Mitchell R., Skaar, Todd C., Von Ah, Diane   +6 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Insights into CYP2B6-mediated drug–drug interactions

Acta Pharmaceutica Sinica B, 2016
Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed. The discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in the ...
William D. Hedrich, Hazem E. Hassan, Hongbing Wang   +2 more
doaj   +1 more source

Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions: Risk factors and impact on indicators of health-related quality of life

Population Medicine, 2022
Introduction While studies have extensively examined the clinical and pharmacokinetic correlates of drug-drug interactions (DDIs) with antiretroviral therapy (ART), less is known about DDIs from the perspective of people living with HIV (PLHIV). Among an
Sejun Park, Yu-Hsiang Hsiao, Fei Yu, Keita Kambara, Brent Allan, Garry Brough, Ta-Fen Hwang, Nathalie Dang, Benjamin Young, Rickesh Patel, Andres Maldonado, Chinyere Okoli   +11 more
doaj   +1 more source

Adaptive HIV-1 evolutionary trajectories are constrained by protein stability [PDF]

, 2017
Despite the use of combination antiretroviral drugs for the treatment of HIV-1 infection, the emergence of drug resistance remains a problem. Resistance may be conferred either by a single mutation or a concerted set of mutations.
Kandathil, Shaun M., Lovell, Simon C., Olabode, Abayomi S., Robertson, David L.   +3 more
core   +2 more sources

Drug prescription clusters in the UK Biobank: An assessment of drug-drug interactions and patient outcomes in a large patient cohort [PDF]

, 2022
Kyriakos Schwarz, Daniel Trejo Baños, Giulia Rathmes, Michael Krauthammer   +3 more
openalex   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source