Results 121 to 130 of about 458,270 (348)
Metabolic properties of the products of mitochondrial protein synthesis in HeLa cells [PDF]
, 1977 The metabolic behavior of the mitochondrial protein synthesis products has been investigated in HeLa cells. Particular attention was given to the four major electrophoretic components (designated as Nos. 2, 3, 5, and 8) of the 10 previously identified as
Attardi, Giuseppe, Costantino, Paolo
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Clinical and Translational Science, 2019 Selecting a dose regimen that is both safe and effective for patients is one of the most critical elements of a successful drug development program. Titrating the dose regimen of a drug based on patient response may help to identify safe and effective ...
Robert N. Schuck +4 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Regulating Functional Foods: Pre- and Post-Market Strategy [PDF]
, 2002 As best we understand the government, its first argument runs along the following lines: that health claims lacking significant scientific agreement are inherently misleading because they have such an awesome impact on consumers as to make it virtually
Ziker, Dana
core +1 more source
Off-label Drugs vs. the Merits of Centralised Regulatory Control [PDF]
, 2008 Ralf Boscheck
openalex +1 more source
Evaluation of Drug Labels Following the 2015 Pregnancy and Lactation Labeling Rule [PDF]
, 2020 John J. Byrne +2 more
openalex +1 more source
Automated unit dose dispensing systems producing individually packaged and labelled drugs for inpatients: a systematic review [PDF]
, 2021 Kaisa Hänninen +3 more
openalex +1 more source