Results 141 to 150 of about 471,442 (349)

Evaluation of color-coded drug labeling to identify endovenous medicines

open access: yesRevista Brasileira de Enfermagem
Objective: To analyze the opinion of nursing professionals on the design, practicality of use and the usefulness of color-coded drug labeling in a pediatric intensive care unit. Methods: A cross-sectional study with 42 nursing professionals.
Nayana Maria Gomes de Souza   +4 more
doaj   +1 more source

Use of Titration as a Therapeutic Individualization Strategy: An Analysis of Food and Drug Administration–Approved Drugs

open access: yesClinical and Translational Science, 2019
Selecting a dose regimen that is both safe and effective for patients is one of the most critical elements of a successful drug development program. Titrating the dose regimen of a drug based on patient response may help to identify safe and effective ...
Robert N. Schuck   +4 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Research of ddi based on multi-label conditional random field

open access: yesBIO Web of Conferences, 2017
The detection of drug name and drug-drug interaction(DDI) is considered as a sequence labeling task in this paper. We present the multi-label CRF method to complete it.
Yu Yangzhi, Deng Hongtao, Zhu Xun
doaj   +1 more source

Metabolic properties of the products of mitochondrial protein synthesis in HeLa cells [PDF]

open access: yes, 1977
The metabolic behavior of the mitochondrial protein synthesis products has been investigated in HeLa cells. Particular attention was given to the four major electrophoretic components (designated as Nos. 2, 3, 5, and 8) of the 10 previously identified as
Attardi, Giuseppe, Costantino, Paolo
core  

Dysfunctional tetraspanin 7 (TSP‐7) in Caenorhabditis elegans promotes; increases in average life‐ & health‐span, stress‐induced survival and motility

open access: yesFEBS Open Bio, EarlyView.
The C. elegans tetraspanin‐7 (tsp‐7) is a homologue of human CD63, which is a negative regulator of autophagy. The C. elegans strain, tm5761, has a dysfunctional (knockout) tsp‐7 gene. When compared to the wild‐type strain, the tm5761 strain shows increased: life‐ and health‐span; thermotolerance, and stress‐induced locomotion.
Brogan Jones   +2 more
wiley   +1 more source

Dietary Supplement Labeling: Cognitive Biases, Market Manipulation & Consumer Choice [PDF]

open access: yes, 2014
There exists increasing concern that the Dietary Supplements Health and Education Act (DSHEA) has proven ineffective. Much of the concern regards the disparity in legislative treatment between dietary supplements, foods, and pharmaceutical drugs. Namely,
McCann, Michael
core   +1 more source

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

open access: yesFEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel   +4 more
wiley   +1 more source

Fluorescence imaging of drug target proteins using chemical probes

open access: yesJournal of Pharmaceutical Analysis, 2020
Fluorescence imaging can provide valuable information on the expression, distribution, and activity of drug target proteins. Chemical probes are useful small-molecule tools for fluorescence imaging with high structural flexibility and biocompatibility ...
Hao Zhu, Itaru Hamachi
doaj  

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