Results 91 to 100 of about 29,922 (309)

Drug release rate and kinetic investigation of composite polymeric nanofibers

, 2016
Objective(s): In this work, electrospun nanofibers were explored as drug delivery vehicles using tetracycline as a model drug.  Nanocomposite fibers including chitosan (CS)/poly (ethylene oxide) (PEO) and antibiotic were successfully prepared using ...
Hassan Hosseini, Aref Mohammadi, Minoo Sadri   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Neighboring Group-Controlled Hydrolysis:  Towards “Designer” Drug Release Biomaterials

, 2016
To give the first demonstration of neighboring group-controlled drug delivery rates, a series of novel, polymerizable ester drug conjugates was synthesized and fully characterized.
Christopher R. Edwards (2481322), Colin P. McCoy (633675), Ryan J. Morrow (2509771), Sean P. Gorman (309201), David S. Jones (633681)   +4 more
core   +1 more source

Smart surface coating of drug nanoparticles with cross- linkable polyethylene glycol for bio-responsive and highly efficient drug delivery [PDF]

, 2016
YesMany drug molecules can be directly used as nanomedicine without the requirement of any inorganic or organic carriers such as silica and liposome nanostructures.
Chen, Xianfeng, Xu, Ruirui, Xu, R., Wei, Weijia, Wei, W., Chen, Xianfeng; id_orcid, Zhou, M., Zhou, Mengjiao, Zhang, X., Zhang, Xiujuan, Zhang, Xiaohong   +10 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Doxorubicin conjugation and drug linker chemistry alter the intravenous and pulmonary pharmacokinetics of a PEGylated Generation 4 polylysine dendrimer in rats [PDF]

, 2018
PEGylated polylysine dendrimers have demonstrated potential as inhalable drug delivery systems that can improve the treatment of lung cancers. Their treatment potential may be enhanced by developing constructs that display prolonged lung retention ...
Leong, Nathania J., Kelly, Brian D., Mehta, Dharmini, Owen, David J., Pathak, Rashmi, McLeod, Victoria M., Porter, Christopher J. H., Kaminskas, Lisa M.   +7 more
core   +1 more source

Relationships Between Hair Chemical Elements and Nutritional Status in Oldest-Old and Centenarian Populations

Journal of Multidisciplinary Healthcare, 2023
Qiao Zhu,1,* Qingkai Zhao,2,* Ping Ping,3,* Qian Zhang,4,* Li Gong,5 Long Feng,6 Yali Zhao,1 Shihui Fu7,8 1Central Laboratory, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, People’s Republic of China ...
Zhu Q, Zhao Q, Ping P, Zhang Q, Gong L, Feng L, Zhao Y, Fu S   +7 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Experimental study: experimental evaluation of phospholipid system containing doxorubicin HCL for use in chemotherapy

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019
Introdution: Common cancer treatment methods have many side effects. Therefore, the use of new methods for drug delivery to cancer cells is necessary. In the present study, nano formulations of lipid carriers containing doxorubicin have been synthesized ...
Syed-Mohammad Moosavizadeh, Morteza Baghiani, Mohammad Majdizadeh, Fatemeh Haghiralsadat, Seyed-Mahmoud Moosavizadeh   +4 more
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source