Results 71 to 80 of about 29,922 (309)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

HISTAMINE LIBERATION INTO THE CEREBROSPINAL FLUID BY THE DRUGS APPLIED INTRAVENTRICULAR!.Y

Japanese Journal of Pharmacology, 1969
Morphine, tubocurarine and veratrine are known to cause motor excitement, hypertension and tachypnea, when they are applied into the cerebrospinal fluid (1-3). Since these drugs have completely different chemical structures, it appears rather strange to elicit analogous excitatory actions on the central nervous system.
TANAKA, KIYOSHI, LIN, YUCHOU
openaire   +3 more sources

In vitro evaluation of PLA nanoparticles containing a lipophilic drug in water-soluble or insoluble form

, 2004
Cloricromene (AD6), an anti-ischemic drug, is rapidly metabolised into a stable and active metabolite (cloricromene acid, AD6-acid) poorly soluble in water and less lipophilic than cloricromene.
FORNI, Flavio, BRINA, Barbara, VANDELLI, Maria Angela, LEO, Eliana Grazia   +3 more
core   +1 more source

A mechanically interlocked molecular system programmed for the delivery of an anticancer drug [PDF]

, 2015
The development of mechanically interlocked molecular systems programmed to operate autonomously in biological environments is an emerging field of research with potential medicinal applications.
Renoux, Brigitte, Clarhaut, Jonathan, Fernandes, Antony E., Papot, Sébastien, Tranoy-Opalinski, I., Barat, Romain, Legigan, Thibaut, Fernandes, Anthony E., Leigh, David A., Tranoy-Opalinski, Isabelle, Poinot, Pauline, Péraudeau, Elodie, Leigh, David, Aucagne, Vincent   +13 more
core   +1 more source

Synthesis and optimization of niosomal carriers containing doxorubicin in order to achieve a final formulation with high potential in cancer cells temperature and acidity

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019
Introdution: Doxorubicin is one of the most commonly used drugs in chemotherapy with many side effects; this fact has limited its use. In the present study, based on the knowledge of pharmaceutical nanocarriers, various formulations of the niosomal form ...
Hashem Shahi Malmir, Seyed Mehdi Kalantar, Elham Sasani, Morteza Asgari, Mohammad Majdizadeh, Bibi Fatemeh Haghiralsadat   +5 more
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The child in American evangelicalism and the problem of affluence: A theological anthropology of the Affluent American-Evangelical Child (AAEC) in late modernity [PDF]

, 2005
This thesis presents an evangelical theology of the child in the context of American evangelicalism and affluence. Employing an eclectic theological- critical method, a theological anthropology of the AAEC is developed through an interdisciplinary ...
Sims, David Α.
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Entwicklung und Charakterisierung von Nanosuspensionen auf Basis erstarrter invers mizellarer Lösungen (SRMS) als ophthalmologisches Drug Delivery System [PDF]

, 2004
Nanosuspensionen auf Basis erstarrter invers mizellarer Lösungen (SRMS, Lecithin (Le)/Hartfett-Mischungen) als ophthalmologisches Drug Delivery System haben zum Ziel, schwer lösliche Arzneistoffe (AS) als wässriges, gut anwendbares System zu formulieren ...
Friedrich, Ingo
core   +1 more source

Chlorogenic acid attenuates cardiac hypertrophy via up‐regulating Sphingosine‐1‐phosphate receptor1 to inhibit endoplasmic reticulum stress

ESC Heart Failure
Aims Cardiac hypertrophy, an adaptive response of the heart to stress overload, is closely associated with heart failure and sudden cardiac death. This study aimed to investigate the therapeutic effects of chlorogenic acid (CGA) on cardiac hypertrophy ...
Ping Ping, Ting Yang, Chaoxue Ning, Qingkai Zhao, Yali Zhao, Tao Yang, Zhitao Gao, Shihui Fu   +7 more
doaj   +1 more source