Results 101 to 110 of about 12,013,030 (353)

Impact of Targeted Temperature Management on ED Patients with Drug Overdose–Related Cardiac Arrest [PDF]

, 2018
Sharaf Khan, Chad Meyers, Suzanne Bentley, Alex F. Manini   +3 more
openalex   +1 more source

Peer Review #2 of "A computer architecture based on disruptive information technologies for drug management in hospitals (v0.1)"

, 2023

openalex   +1 more source

Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease

Drug Delivery, 2018
In recent years, the incidental rate of neurodegenerative disorders has increased proportionately with the aging population. Alzheimer’s disease (AD) is one of the most commonly reported neurodegenerative disorders, and it is estimated to increase by ...
Govindarajan Karthivashan, P. Ganesan, Shin-Young Park, Joonsoo Kim, D. Choi   +4 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Antimicrobial drug usage pattern in poultry farms in Nigeria: implications for food safety, public health and poultry disease management.

, 2021
Emmanuel Okechukwu Njoga, Akwoba Joseph Ogugua, Innocent Okwundu Nwankwo, Olajoju Jokotola Awoyomi, Chinwe E. Okoli, Deborah Maigawu Buba, Felix A. Oyeleye, Festus Ejike Ajibo, Nichodemus Azor, Temitope Mofoluso Ogunniran   +9 more
openalex   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

From information management to protein annotation: preparing protein structures for drug discovery [PDF]

, 2002
Thomas S. Peat, Eric de La Fortelle, Janice Culpepper, Janet Newman   +3 more
openalex   +1 more source

Optimal management of drug-resistant tuberculosis: Can India lead the way?

, 2023
Tiziana Masini, Jennifer Furin, Zarir Udwadia, Lorenzo Guglielmetti   +3 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

brinolytic Drug Therapy in the Management of Intravascular Thrombosis, Especially Acute Myocardial Infarction - A Review [PDF]

, 2017
Vivek Lal
openalex   +1 more source