Results 101 to 110 of about 1,066,064 (314)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Drug management of autosomal dominant polycystic kidney disease. [PDF]
Theivendran T, Ramachandran A, Rangan G.
europepmc +1 more source
Home case management of malaria: an ethnographic study of lay people's classification of drugs in Suneka Division, Kenya [PDF]
Isaac K. Nyamongo
openalex +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Drug Development Pipeline for Myeloproliferative Neoplasms: Potential Future Impact on Guidelines and Management [PDF]
Prithviraj Bose, Srđan Verstovšek
openalex +1 more source
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Background Glaucoma is the leading cause of irreversible blindness in Japan and constitutes a serious public health challenge. Due to its asymptomatic onset and slow progression, patient persistence with topical glaucoma therapies remains low ...
Kenji Kabeya +3 more
doaj +1 more source
The Dilemma of Treating Delirium: the Conundrum of Drug Management. [PDF]
Agar MR, Amgarth-Duff I.
europepmc +1 more source

