Results 71 to 80 of about 848,131 (265)

Pharmacodynamic-Driven Sequence-Dependent Synergy Effects in Pemetrexed-Osimertinib Combination Against Non-Small Cell Lung Cancer (NSCLC): Optimizing Synergy Through Sequential Interval

Pharmaceutics
Background: Combining pemetrexed (PEM) with Osimertinib (OSI) improves outcomes in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), but optimal scheduling remains undefined. Sequential PEM → OSI strategies may outperform
Kuan Hu, Yu Xia, Tong Yuan, Yan Lin, Jin Yang   +4 more
doaj   +1 more source

Increased Levels of Fatty Acids Contributed to Induction of Hepatic CYP3A4 Activity Induced by Diabetes — In Vitro Evidence From HepG2 Cell and Fa2N-4 Cell Lines

Journal of Pharmacological Sciences, 2014
Accumulating evidences have shown that diabetes upregulated the function and expression of CYP3A4, but the mechanism remained unclear. In this study, HepG2 cells were incubated with serum from diabetic rats induced by streptozotocin, and the activity of ...
Nan Hu, Mengyue Hu, Ru Duan, Can Liu, Haifang Guo, Mian Zhang, Yunli Yu, Xinting Wang, Li Liu, Xiaodong Liu   +9 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Aging, Drugs, and Drug Metabolism [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2011
David G, Le Couteur, Andrew J, McLachlan, Rafael, de Cabo   +2 more
openaire   +2 more sources

Metabolism of drugs by the kidney

Kidney International, 1980
The kidneys have many clearly defined physiologic functions. Although their role as an excretory organ for drugs and chemicals and their polar metabolites is well described, their involvement in the biotransformation of xenobiotics is relatively poorly understood.
openaire   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

DRUG METABOLISM

Medical Journal of Australia, 1979
G G, Graham, M, Kennedy
openaire   +4 more sources

The classic azole antifungal drugs affect steroidogenic activity in a human term placenta model

Pharmacological Research
During pregnancy there is an increased risk of vulvovaginal candidiasis that if left untreated is associated with pregnancy complications. First choice of treatment are over-the-counter azole antifungal drugs (AADs): miconazole, and clotrimazole, or ...
Line Mathiesen, Lisa Hoyng Alstrup, Stine Buchholdt, Diana Petra Sjöberg-Guttesen, Ida Elise Mølgaard Hammer, Rikke Sjøgren Koch, Anna Christine Drachmann Kragh, Dea Sandal, Isabella Dubiel Stæhr, Caroline Agerlin Ødum, Malene Louise Johannsen, Flemming Steen Jørgensen, Christian Janfelt, Lisbeth E. Knudsen, Bjarne Styrishave   +14 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity

Journal of Lipid Research, 1997
The hypocholesterolemic activity for novel ureido fibrate analogues was found to be over 100-fold greater than for any “second-generation” fibrate in cholesterol-fed rats. A comparison of 12 related analogues revealed that the optimal configuration for a
R L Hawke, J M Chapman, D A Winegar, J A Salisbury, R M Welch, A Brown, K W Franzmann, C Sigel   +7 more
doaj   +1 more source