Results 211 to 220 of about 249,494 (353)

A scoping review of thresholds for responder and time‐to‐event analysis of patient‐reported outcomes in breast cancer trials

British Journal of Clinical Pharmacology, EarlyView.
Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner, Daniela Krepper, Micha Johannes Pilz, Lisa Marie Storz, Maike Thumfart, Johannes Maria Giesinger   +5 more
wiley   +1 more source

Prospective associations of alcohol and drug misuse with suicidal behaviors among US Army soldiers who have left active service. [PDF]

Psychol Med
Campbell-Sills L, Sun X, Kessler RC, Ursano RJ, Jain S, Stein MB.   +5 more
europepmc   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Empowerment in prevention: a qualitative inquiry into Black girl-centred strategies for reducing HIV/STI and drug misuse risk. [PDF]

Sex Reprod Health Matters
Opara I, Asabor E, Rutledge J, Brooks Stephens JR, Cayo S, Duran-Becerra B, Abrams J.   +6 more
europepmc   +1 more source

Ocular candidiasis in intravenous drug misusers

, 2016
Delphine Lam, Rafik Belazzougui, Christine Fardeau, Valérie Touitou, Phuc LeHoang, Yves Edel, Bahram Bodaghi   +6 more
openalex   +1 more source

Exploring the consequences of how Scotland interprets the UK Misuse of Drugs Act 1971

, 2012
John McPhee, Colin R. Martin, Anthony Sneider   +2 more
openalex   +2 more sources

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Experiences of sexist discrimination as a potential explanatory factor for alcohol and drug misuse among Latina young adult women. [PDF]

Soc Sci Med
Ertl MM, Chu A, Duncan LJ, Fresquez CL.
europepmc   +1 more source

The influence of the built environment on drug misuse and abuse

Adewumi Oladele, Edward Onyango, Kyle Esdaille   +2 more
openalex   +2 more sources

Trends and variation in the use of andexanet alfa for the reversal of direct oral anticoagulants in NHS trusts in England

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Andexanet alfa was recommended by the National Institute for Health and Clinical Excellence (NICE) as an option in the management of life‐threatening gastrointestinal bleeding in patients taking apixaban or rivaroxaban in May 2021. A recent UK‐wide survey of local hospital protocols for the use of andexanet alfa suggested that practice ...
Louis Fisher, Richard Buka, Rosalind Byrne, Stephen Black, Helen J. Curtis, Christopher Wood, Andrew Brown, Sebastian Bacon, Richard Croker, Ben Goldacre, Brian MacKenna, Victoria Speed   +11 more
wiley   +1 more source